BACKGROUND Although cerebral arterial stiffness may be an important marker for cerebrovascular health, there is not yet a measurement that accurately reflects the distensibility of major intracranial arteries. Herein, we aim to noninvasively measure distension of the human middle cerebral artery (MCA). METHODS Ten healthy volunteers (age: 30.3 ± 10.8 years) underwent ultra-high-field (7-tesla...

BACKGROUND Left ventricular dysfunction, mediated by ventricular interdependence, has been associated with negative outcomes in children with pulmonary arterial hypertension (PAH). Considering the dilation of the pulmonary arteries as a paramount sign of PAH, we hypothesized that the ascending aorta will present signs of apparent stiffness in children with PAH and that this effect may be becaus...

BACKGROUND Although higher visit-to-visit variability (VVV) of blood pressure (BP) is associated with increased cardiovascular disease risk, the physiological basis for VVV of BP is incompletely understood. METHODS We examined the associations of aortic distensibility (assessed by magnetic resonance imaging) and artery elasticity indices (determined by radial artery pulse contour analysis) wi...

BACKGROUND Cardiovascular magnetic resonance (CMR) has been validated for the noninvasive assessment of total arterial compliance and aortic stiffness, but their associations with cardiovascular outcomes is unknown. The purpose of this study was to evaluate associations of CMR measures of total arterial compliance and two CMR measures of aortic stiffness with respect to future cardiovascular ev...

Importance of Pressure Pulse Amplification in the Association of Resting Heart Rate and Arterial Stiffness To the Editor: The study by Whelton et al1 shows that resting heart rate is independently associated with arterial stiffness. Arterial stiffness was quantified as distensibility and determined from ultrasound measurements of carotid diameter and MRI measurements of aortic diameter. Distens...

Background and AimsThe role of decreased pyloric distensibility in gastroparesis as measured by the endolumenal functional luminal imaging probe (EndoFLIP) has been receiving increasing attention. In this study, we present clinical outcomes to dilation with esophageal FLIP (EsoFLIP) regard gastric emptying, symptom evolution, metrics.MethodsPatients evaluated for (gastric emptying studies t1/2 ...