Esophageal distension and transient lower esophageal sphincter (LES) relaxation (TLESR) are accompanied by simultaneous relaxation of the LES and inhibition of crural diaphragm. Recent studies indicate that baclofen decreases the frequency of TLESR; however, its effect on the crural diaphragm is not known. We evaluated the effects of baclofen on LES relaxation and crural diaphragm inhibition in...

BACKGROUND Patients who complain of constipation can be divided into those who have lost the natural call to stool, but develop abdominal discomfort after several days without a bowel movement (no urge); and those who experience a constant sensation of incomplete evacuation (urge). AIMS To determine whether the two groups differ in symptoms, colonic transit, and perceptual responses to contro...

The effect of distension of the fundus and body of the stomach on gastric acid secretion was studied in 26 patients with duodenal ulcer and six healthy subjects. Graded distension produced by inflating a rubber balloon to volumes of 150, 300, and 600 ml resulted in significant sequential increments of acid output. The secretory response outlasted stimulation by at least one hour. In both groups...

The incidence of pelvic spreading of endometrial cells at diagnostic hysteroscopy was studied comparing the two distension media carbon dioxide (CO(2)) and normal saline (N/Saline). Thirty patients requiring laparoscopy and hysteroscopy were included in this study, the main indication for surgery being subfertility. Hysteroscopy was performed using both CO(2) and N/Saline distension on each pat...

Responses of the cricopharyngeal sphincter to graded intraluminal distension were studied in order to determine its response threshold and to define the functional relationship between the sphincter and oesophageal body. Nine normal subjects underwent manometric study using a multilumen tube with an attached inflatable balloon sited 10 cm below the sphincter. Sphincteric and oesophageal motor r...

Frozen shoulder is a chronic fibrosing condition of capsule of shoulder joint. The purpose of this study was to evaluate the efficacy of hydraulic distension in the treatment of frozen shoulder. 50 Patients with 54 shoulders of frozen shoulder syndrome were treated with hydraulic distension and steroid under local anesthesia from July 2014 to August 2016.Various parameters like pain, range of m...

Abstract Background The enteric nervous system (ENS) is the extensive neural network within wall of gastrointestinal (GI) tract that essential for control gut function. However, mechanisms whereby ENS responds to mechanical forces associated with distension are not well understood, and this has implications function in health disease. Purpose This study aims determine underlying responsiveness ...