Shelterin is a six-subunit protein complex that plays crucial roles in telomere length regulation, protection, and maintenance. Although several shelterin subunits have been studied in vitro, the biochemical properties of the fully assembled shelterin complex are not well defined. Here, we characterize shelterin using ensemble biochemical methods, electron microscopy, and single-molecule imagin...

By using the Jensen-Shannon divergence, genomic DNA can be divided into compositionally distinct domains through a standard recursive segmentation procedure. Each domain, while significantly different from its neighbors, may, however, share compositional similarity with one or more distant (non-neighboring) domains. We thus obtain a coarse-grained description of the given DNA string in terms of...

I will survey in this talk two papers written in collaboration with Bela Bollobas, Don Coppersmith, and Greg Sorkin. The second of these papers studies how Euler circuits for a type of Eule-rian, directed graphs, can be counted by a recursion relation. Generalizing this recursion relation deenes a polynomial, the interlace polynomial, on any undirected graph. We introduce this new polynomial an...

This paper introduces a new family of reconstruction codes which is motivated by applications in DNA data storage and sequencing. In such applications, strands are sequenced reading some subset their substrings. While previous works considered two extreme cases all substrings pre-defined lengths read or with no overlap for the single string case, this work studies extensions paradigm. The first...

Objective: Now it's a worldwide issue that carbapenem resistance is spreading. This has made K. pneumoniae infections more difficult to treat. All Klebsiella pneumonia's proteins were examined in this study, which focused on the carbapenem-resistant bacteria's response meropenem. Methods: Proteomics (MALDI-TOF) and bioinformatics methods combined answer new enigma of resistance. Functional anno...

Deoxyribonucleic acid (DNA) sequence classification is a fundamental task in computational biology with vast implications for applications such as disease prevention and drug design. Therefore, fast high-quality classifiers are significantly important. This article introduces ClaPIM, scalable DNA architecture based on the emerging concept of hybrid in-crossbar near-crossbar memristive processin...