The group B streptococcus (GBS) is an important human pathogen with the ability to cause invasive disease. To do so, the bacteria must invade host cells. It has been well documented that GBS are able to invade a variety of nonphagocytic host cell types, and this process is thought to involve a number of pathogen-host cell interactions. While some of the molecular aspects of the GBS-host cell in...

A trans-dominant mutational strategy was used to down-regulate trypanothione reductase (TR) activity levels in Leishmania donovani, the causative agent of visceral leishmaniasis in humans. TR, regarded as an ideal drug target against trypanosomatid infections, is a homodimeric flavoprotein oxidoreductase unique to these organisms that plays a central role in the enzymatic regeneration of the th...

IgA-dominant acute postinfectious glomerulonephritis (APIGN) is an increasingly recognized morphologic variant of APIGN, particularly in the elderly. In contrast to classic APIGN, in which there is typically glomerular deposition of IgG and C3 or C3 only, IgA is the sole or dominant immunoglobulin in IgA-dominant APIGN. Because the vast majority of reported cases occur in association with staph...

HIV epitope-specific T cell responses are often comprised of clonotypic expansions with distinct functional properties. In HIV(+) individuals, we measured programmed death-1 (PD-1) and IL-7Rα expression, MHC class I tetramer binding, cytokine production, and proliferation profiles of dominant and subdominant TCR clonotypes to evaluate the relationship between the composition of the HIV-specific...

Female Gryllus bimaculatus have been found to prefer dominant males as mates, and dominant males have shown to have a higher encapsulation rates and higher lytic activities. However, previous studies were conducted with crickets from the laboratory stock culture population that has been in the laboratory for years. Under laboratory conditions, low rates of natural parasites and pathogens may ca...

background: neurobrucellosis is a rare complication of brucellosis. acute meningitis and encephalitis are the most common clinical manifestations; however, symptoms of these two conditions may be subacute and diagnosis requires a high index of suspicion in patients from endemic areas. diagnosis is often based on neurological symptoms, serology, and suggestive brain imaging because cerebrospinal...

When examining the history of religions and dominant religious narratives, institutions, cultures, ideologies, practices in contemporary world, one is tempted to conclude that religion more problem relating diverse issues war peace. Dominant cultures seem overwhelmingly be causes, express systemic structures, provide ideological, theological, philosophical justifications for violence, war, mili...

[sic] – a Journal of Literature, Culture and Literary Translation focuses on theoretical, empirical artistic research in the fields culture, literature literary translation. thus welcomes submission works that focus various theoretical or problems within listed above, as well original translations. By publishing papers, video essays, reviews, criticism, interviews translation, wishes to offer w...

[sic] – a Journal of Literature, Culture and Literary Translation focuses on theoretical, empirical artistic research in the fields culture, literature literary translation. thus welcomes submission works that focus various theoretical or problems within listed above, as well original translations. By publishing papers, video essays, reviews, criticism, interviews translation, wishes to offer w...

[sic] – a Journal of Literature, Culture and Literary Translation focuses on theoretical, empirical artistic research in the fields culture, literature literary translation. thus welcomes submission works that focus various theoretical or problems within listed above, as well original translations. By publishing papers, video essays, reviews, criticism, interviews translation, wishes to offer w...