Drug delivery technology is emerging as an interdisciplinary science aimed at improving human health. The controlled delivery of pharmacologically active agents to the specific site of action at the therapeutically optimal rate and dose regimen has been a major goal in designing drug delivery systems. Over the past few decades, there has been considerable interest in developing biodegradable dr...

BACKGROUND Low-molecular-weight heparins (LMWH) are the most commonly used anticoagulant during pregnancy for prevention or treatment of VTE. However, the size of the associated risk of postpartum haemorrhage (PPH) is unknown. OBJECTIVE To assess the bleeding risk of high dose LMWH, also in relation to time between last dose LMWH and delivery. MATERIAL AND METHODS From 1999 to 2009, we foll...

The low tidal volume and flow in preschool children may reduce the efficiency of aerosol delivery from a pressurized metered-dose inhaler (pMDI) through a traditional holding chamber. A prototype small-volume steel holding chamber with two one-way valves was devised to prolong aerosol availability in the chamber and to ensure unidirectional airflow. Dead space between the valves was minimized t...

Current state-of-the art digital C-arm medical linear accelerators are capable of delivering radiation treatments with high level of automation, which affords coordinated motions of gantry, couch, and multileaf collimator (MLC) with dose rate modulations. The new machine capacity has shown the potential to bring substantially improved radiation dosimetry and/or delivery efficiency to many chall...

In this study, a 4D dosimetry concept was developed. This concept included a method for calculation of 3D reference absorbed dose matrices at every control point of the delivery using a clinical treatment planning system (TPS). Further, the gamma evaluation method was extended to incorporate the 4 dimension of the TPS calculated dose distributions. The applications of the 4D dosimetry concept o...

background very few studies have assessed performance of botswana public hospitals. we draw from a large research study assessing performance of the botswana ministry of health (moh) to evaluate the performance of public hospital system using the world health organization health systems performance assessment framework (who hspaf). we aimed to evaluate performance of botswana public hospital sy...

drug-in-adhesive transdermal drug delivery systems  )tddss) containing stimulants, termed as energetic substances, such as caffeine and pantothenic acid, were studied. caffeine is a white crystalline substance and a stimulant to central nervous system. in humans, caffeine acts as a central nervous system stimulant, temporarily warding off drowsiness and restoring alertness. pantothenic acid, al...

oral ph sensitive drug delivery systems are of utmost importance as these systems deliver the drug at specific part of the gastrointestine (gi) as per the ph of gi, resulting in improved patient therapeutic efficacy and compliance. the ph range of fluids in various segments of the gi tract may provide environmental stimuli for drug release. the aim of this study was to design buoyant beads cont...