Responsiveness to inhaled methacholine was compared before and 40-60 minutes after a challenge with ultrasonically nebulised water (UNH2O) in 16 asthmatic patients. The sensitivity to methacholine increased after UNH2O challenge (p less than 0.001). The mean dose of methacholine producing a 20% fall in forced expiratory volume in one second was 0.4 (95% confidence limits 0.2, 0.8) mumol, compar...

Using a high-affinity antibody for estradiol, thermodynamic and experimental limitations on detection limits for competitive capillary electrophoretic immunoassays were examined. Theoretical modeling of the dose-response curves for such assays allowed for optimization of experimental conditions. Through the examination of experimental and theoretical results generalizations could be made as to ...

Radon, together with its progeny, is present in high levels in some underground sites. Radon is known to increase the risk of lung cancer, while increased levels of radon decay products on the skin surface have been implicated in skin cancer induction and at sufficient levels might cause deterministic effects such as erythema. Although radon levels in working mines are controlled, radon in aban...

Introduction: In brachytherapy, as in external radiotherapy, image-guidance plays an important role. For GYN treatments it is standard to acquire at least CT images and preferably MR images prior to each treatment and to calculate the dose of the day on each set of images. Then, the dose to the target and to the organs at risk (OAR) is calculated with worst case scenario from I...

Background: Assessment of activity concentrations of 238U, 232Th, 40K and gamma dose rate (DR) was carried out over a laterite mining field in Ilorin-south, Nigeria. Materials and Methods: A well calibrated Super-Spec (RS-125) gamma spectrometer was used to measure the activity concentrations of 40K, 238U, 232Th and gamma doses rate at 1 m above the ground level over the laterite mining field. ...

The effect of gamma irradiation on neat Polyamide-11 (PA11) and PA11 filled with 3 wt% halloysite nanotubes (HNTs) was investigated at various doses up to 100 kGy in air room temperature. test conducted sample films prepared by a twin-screw extruder the first step then cast extrusion. study showed formation maximum gel fraction 10 20 for PA11/HNTs, respectively. Furthermore, results indicated o...

A bioequivalence study of two verapamil formulations (generic verapamil tablets and Isoptin® tablets) was performed by comparing pharmacokinetic parameters of the parent drug and its major metabolite, norverapamil following a single dose administration of 80 mg verapamil hydrochloride in 22 healthy volunteers according to a randomized, two-period, crossover-design study. Moreover, the feasibili...

BACKGROUND Rickettsia typhi (R. mooseri) is the causative agent of murine typhus. It is one of the most widely distributed flea-borne diseases with a relatively mild febrile initial illness with six to 14 days of incubation period. The bacterium is gram negative and an obligate intracellular pathogen. The disease is transmitted to humans and vertebrate host through fleabites or via contact with...