PURPOSE To determine the optimal dose of the antiepidermal growth factor receptor (EGFR) monoclonal antibody cetuximab that can be safely administered in combination with a standard daily dose of erlotinib in patients with advanced solid malignancies. PATIENTS AND METHODS Patients with advanced solid malignancies who had failed standard chemotherapies received escalating doses of cetuximab wi...

The SHAAD model (Adaptable, Adaptive and Dynamic Hypermedia System) allows adapting the web content delivered to the user based on his/her preferences and characteristics, and the features and limitations of the device used to interact with the system. In this work we use CC/PP (Composite Capabilities/Preference Profiles) to describe the characteristics of devices and users’ preferences. Finall...

BACKGROUND Megavoltage beams used in radiotherapy are contaminated with secondary electrons. Different parts of linac head and air above patient act as a source of this contamination. This contamination can increase damage to skin and subcutaneous tissue during radiotherapy. Monte Carlo simulation is an accurate method for dose calculation in medical dosimetry and has an important role in optim...

Introduction: Intraoperative radiotherapy is a radiotherapy technique in which a high single fraction of radiation dose is delivered to the patient after surgery and Concurrent with anesthesia time. The most frequent method for IORT implementation is Intraoperative electron radiotherapy (IOERT), in which, some dedicated and high dose per pulse electron accelerators are employe...

The Proton Therapy Center in Orsay (CPO) and CEA/DAPNIA launched the joint project on Monte Carlo modeling of a CPO beam line with the aim to achieve a prediction of dose distribution in all the calibration configurations (depth and the shape of the tumor) better than 2%. The calculation module is intended to be used for the absolute dosimetry of the clinical beam (patient Quality Assurance – Q...

In this work isodose curves are obtained by the use of a new dosimetric algorithm using numerical data from percentage depth dose (PDD) and the maximum absorbed dose profile, calculated by Monte Carlo in a 18 MV LINAC. The software allows reproducing the absorbed dose percentage in the whole irradiated volume quickly and with a good approximation. To validate results an 18 MV LINAC with a whole...

Because of the adverse effects of ionizing radiation on fetuses, prior to radiotherapy of pregnant patients, fetal dose should be estimated. Fetal dose has been studied by several authors in different depths in phantoms with various abdomen thicknesses (ATs). In this study, the effect of maternal AT and depth in fetal dosimetry was investigated, using peripheral dose (PD) distribution evaluatio...