BACKGROUND This study investigates the use of TomoDirect™ 3DCRT for whole breast adjuvant radiotherapy (AWBRT) that represents a very attractive treatment opportunity, mainly for radiotherapy departments without conventional Linacs and only equipped with helical tomotherapy units. METHODS Plans were created for 17 breast cancer patients using TomoDirect in 3DCRT and IMRT modality and field-in...

BACKGROUND Radiation to the neck has long been associated with an elevated risk of hypothyroidism development. The goal of the present work is to define dosimetric predictors of hypothyroidism in oropharyngeal cancer (OPC) patients treated with intensity-modulated radiation therapy. METHODS Data for 123 patients, with a median follow up of 4.6 years, were retrospectively analyzed. Patients wi...

The present work is devoted to develop a computational model using the Monte Carlo code MCNP5 (Monte Carlo N-Particle) for the simulation of a 6 MV photon beam given by Elekta Precise medical linear accelerator treatment head. The model includes the major components of the multileaf accelerator head and a cube-shaped water tank. Calculations were performed for a photon beam with 10 cm x 10 cm i...

The Elekta Versa HD incorporates a variety of upgrades to the line of Elekta linear accelerators, primarily including the Agility head and flattening filter-free (FFF) photon beam delivery. The completely distinct dosimetric output of the head from its predecessors, combined with the FFF beams, requires a new investigation of modeling in treatment planning systems. A model was created in Pinnac...

BACKGROUND The radiation tolerance dose-volume in brain remains unclear for nasopharyngeal carcinoma (NPC) patients treated with intensity modulated radiotherapy (IMRT). We performed this study to investigate dosimetric factors associated with temporal lobe necrosis (TLN) in NPC patients treated with IMRT. METHODS From 2001 to 2008, 870 NPC patients were treated with IMRT. For the whole group...

The purpose of this work was to determine the dosimetric benefit to normal tissues by tracking the multi-leaf collimator (MLC) apertures with the photon jaws in step-and-shoot intensity-modulated radiation therapy (IMRT) on the Varian 2100 platform. Radiation treatment plans for ten thoracic, three pediatric, and three head and neck cancer patients were converted to plans with the jaws tracking...

We investigate the sensitivity of IMRT commissioning using the TG-119 C-shape phantom and credentialing with the IROC head and neck phantom to treatment planning system commissioning errors. We introduced errors into the various aspects of the commissioning process for a 6X photon energy modeled using the analytical anisotropic algorithm within a commercial treatment planning system. Errors wer...

The Delta4 3D dose verification device was commissioned in the current work for pre-treatment quality assurance (QA) of Intensity Modulated Radiotherapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) plans. The cross calibration and relative array calibration were performed to enable absolute dose comparison. The linearity of response with dose and temperature sensitivity tests were also co...

objective(s): in this study we evaluate the impact of the different aspects of gold nano-particles (gnps) on the target absorptive dose enhancement factor (def) during external targeted radiotherapy with photon beams ranging from kilovolt to megavolt energies using monte carlo simulation. methods: we have simulated the interaction of photon beams with various energies of radiation using water s...