The rationale for using multiple inhibitors between and within the phosphoinositide 3-kinase/AKT/mTOR and RAS/MEK/ERK pathways is scientifically compelling, and a limited number of experimental agents are currently being tested in phase I combinations. Patient subpopulations, whose tumors are defined by genetic lesions, are showing promising responses to this approach.

An 80-year-old man had intraoperative loss of an intraocular lens (IOL) in the vitreous and simultaneous implantation of an anterior chamber lens. For the first 3 years his course was uncomplicated, but after this time he noted monocular double vision. The IOL in the vitreous had moved into the optic axis of the eye. The case presented here underlines the possibility of complications occurring ...

Formulae expressing explicitly the coefficients of an expansion of double Jacobi polynomials which has been partially differentiated an arbitrary number of times with respect to its variables in terms of the coefficients of the original expansion are stated and proved. Extension to expansion of triple Jacobi polynomials is given. The results for the special cases of double and triple ultraspher...

conclusions this study showed that a pneumatic arm tourniquet as an adjunct to ivra provides acceptable analgesia following the deflation of the double- cuff tourniquet for relieving surgical pain. results the mean operation time after the deflation of the double-cuff tourniquet was 20.12 ± 6.1 minutes. moreover, the mean nrs for the post-deflation time was insignificant (nrs = 2), and only one...

The development of constrained peptides for inhibition of protein-protein interactions is an emerging strategy in chemical biology and drug discovery. This manuscript introduces a versatile, rapid and reversible approach to constrain peptides in a bioactive helical conformation using BID and RNase S peptides as models. Dibromomaleimide is used to constrain BID and RNase S peptide sequence varia...

 The concept of statistical convergence in $2$-normed spaces for double sequence was introduced in [S. Sarabadan and S. Talebi, {it Statistical convergence of double sequences  in $2$-normed spaces }, Int. J. Contemp. Math. Sci. 6 (2011) 373--380]. In the first, we introduce concept strongly statistical convergence in $2$-normed spaces and generalize some results. Moreover,  we define the conce...

S U M M A R Y Stacks of SS precursors have been widely used in the past two decades to investigate the existence and characteristics of upper mantle discontinuities on a global scale as well as in several regional cases. Here, we present observations of SS precursors from an Mb 6.7 earthquake recorded at the US Transportable Array in 2010. In this particular case, the S660S precursors on the tr...

the objective of these investigation were use of berseem clover (trifolium alexandrinum ) in double cropping system (after autumns crop) to improve forage production in shahrekord region. the experiments were carried out in the preliminary, research and farmer field condition in 2005, 2006-7 and 2013 respectively. in 2005 the results showed that there is possibility of double cropping of bersee...

conclusions this nonrandomized comparison of stent types in kidney transplantation supports the use of prophylactic double-j stents in terms of decreased ureteric complications and reduced length of hospital stay. patients and methods a retrospective analysis was performed on data of renal transplantations performed at our institution in a 12-month period. in this period, external and double-j ...