The inhibition of succinate oxidation by malonate is a well known phenomenon. Since the oxidation of succinate to fumarate is an integral part of the Krebs cycle of oxidations, it has been generally assumed that the inhibitory effect of malonate upon the oxidation of any member of the cycle is the result of the inhibition of the succinate to fumarate step. However, the present paper provides ev...

Genotypically different host specific pathotypes of Bursaphelenchus xylophilus have been identified. These pathotypes elicit different responses in pines depending on susceptibility, tolerance, or resistance. Continued passage of some of these pathotypes on fungal cultures leads to conversion to nonparasitic populations. These populations metabolize carbon substrates to ethanol by an anaerobic ...

BACKGROUND The market of hypnotic and sedative drugs is being updated due to the high toxicity barbiturates limitations their use. Currently, safer such as Z-drugs, Doxylamine, some benzodiazepine derivatives are often prescribed for treatment anxiety insomnia, but they can cause acute poisoning if overdosed or in case nonmedical AIM To establish an affordable express thin-layer chromatography ...

Succinate dehydrogenase (SDH) is a multifaceted enzyme for the mitochondria of eukaryotes, which responsible converting succinate to fumarate as component in Krebs cycle. Its dysfunction occurs several malignancies associated with endocrine and epithelial tumors. SDH an enzymatic complex made some subunits. recognized oncometabolite; therefore, discovery mutations can give straight connection b...

The succinate receptor (also known as GPR91) is a G protein-coupled receptor that is closely related to the family of P2Y purinoreceptors. It is expressed in a variety of tissues, including blood cells, adipose tissue, the liver, retina, and kidney. In these tissues, this receptor and its ligand succinate have recently emerged as novel mediators in local stress situations, including ischemia, h...

The influence of succinate treatment on Zn toxicity was investigated using plant growth and mineral uptake as stress indicators. Pea plants (Pisum sativum L., cv. Citrine) were treated with various Zn concentrations (0.67 to 700 μM Zn) in the presence and absence of 0.2 mM Na-succinate. Plants pre-treated with succinate and then exposed to Zn exhibited higher dry root, stem and leaf weight than...

The metabolic conversion of dicarboxylic acids into succinate and other gluconeogenic intermediates in rat liver homogenates was investigated using [1,2,4-13C4]dodecanedioic acid as tracer. Isotope enrichments in 3-hydroxybutyrate, succinate, fumarate, and malate, as well as dicarboxylates (dodecanedioic, sebacic, suberic, and adipic acids) were measured with selected ion monitoring capillary c...

We previously engineered E. coli YL104H to efficiently produce succinate from glucose. Furthermore, the present study proved that YL104H could also co-utilize xylose and glucose for succinate production. However, anaerobic succinate accumulation using xylose as the sole carbon source failed, probably because of an insufficient supply of energy. By analyzing the ATP generation under anaerobic co...

Factors controlling the rate of oxidation of succinate were studied in mitochondria isolated from twenty-seven specimens of normal human liver obtained at operation. These were compared with mitochondria prepared from the livers of anesthetized and unanesthetized rats. Previously reported lower rates of succinate oxidation by human liver mitochondria were confirmed. This difference was no longe...