12 Abstract In this study we describe a mechanism for supporting a community of 13 learning scientists who are exploring educational technologies by helping them to 14 share and collaboratively build design knowledge. The Design Principles Database 15 (DPD) is intended to be built and used by this community to provide an infrastructure 16 for participants to publish, connect, discuss and review...

INTRODUCTION The aim of the study was to compare the effects of amiloride and bumetanide on the baseline transepithelial electrical potential difference (PD) and changes in PD during mechanical stimulation (dPD) in isolated cecal and colonic wall of rabbits. MATERIAL/METHODS The experiments were performed with a modified Ussing chamber system. Isolated tissue specimens were incubated in Ringe...

INTRODUCTION Development of DNA-based tests for TPMT/DPD polymorphisms can help clinicians and patients to make important decisions about cancer treatment. Also, due to lack of Indian data, we aimed at the development and validation of these tests in Indian patients. MATERIALS AND METHODS Molecular assays were used for identifying TPMT/DPD variations; validated by DNA sequencing. RESULTS Mo...

Introduction: Our target was to retrospectively examine the results of Sacral Nerve Modulation (SNM) in patients complaining of simultaneous bladder and the rectum dysfunctions, here called double pelvic dysfunction (DPD). Methods: In 2009, in six Italian centres, patients treated with SNM were asked to complete a self-assessment questionnaire for DPD. The questionnaire investigated the changes...

AIMS The aim of the Danish Palliative Care Database (DPD) is to monitor, evaluate, and improve the clinical quality of specialized palliative care (SPC) (ie, the activity of hospital-based palliative care teams/departments and hospices) in Denmark. STUDY POPULATION The study population is all patients in Denmark referred to and/or in contact with SPC after January 1, 2010. MAIN VARIABLES Th...

We study numerical methods for dissipative particle dynamics (DPD), which is a system of stochastic differential equations and popular momentum-conserving thermostat simulating complex hydrodynamic behavior at mesoscales. propose new splitting method that able to substantially improve the accuracy efficiency DPD simulations in wide range friction coefficients, particularly extremely large limit...

Status of this Memo This memo provides information for the Internet community. It does not specify an Internet standard of any kind. Distribution of this memo is unlimited. Abstract This document specifies the requirements for Delegated Path Validation (DPV) and Delegated Path Discovery (DPD) for Public Key Certificates. It also specifies the requirements for DPV and DPD policy management.

Dihydropyrimidine dehydrogenase (DPD), the first enzyme in the sequential metabolism of pyrimidine, regulates blood concentrations of 5-fluorouracil and is deeply involved in its toxicity. This study was designed to examine the effects of a DPD inhibitor on blood concentrations of [2-(13)C]uracil ([(13)C]uracil) and (13)CO(2) concentration (Delta(13)C) expired in breath after oral or intravenou...

Dihydropyrimidine dehydrogenase (DPD), the initial, rate-limiting step in pyrimidine degradation, was studied in two cell lines of murine neuroblastoma (MNB-T1 and MNB-T2) that were derived from C-1300 MNB tumor carried in A/J mice. The MNB-T2 (low malignancy) cell line was originally derived from the in situ tumor and carried in tissue culture for more than 100 passages; the MNB-T1 (high malig...