Submit Manuscript | http://medcraveonline.com Abbreviations: PCMH: Patient Centered Medical Home; SGLT-2 Inhibitors: Sodium Glucose Cotransport-2 Inhibitors; T2DM: Type 2 Diabetes; A1c: Hemoglobin A1c; SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure; Egfr: Estimated Glomerular Filtration Rate; CDC: Centers For Disease Control; ADA: American Diabetes Association; AACE: American Acade...

DPP4 inhibitors and GLP-1 receptor agonists used in incretin-based strategies treat Type 2 diabetes with different modes of action. The pharmacological blood GLP-1R agonist concentration targets pancreatic and some extrapancreatic GLP-1R, whereas DPP4i favors the physiological activation of the gut-brain-periphery axis that could allow clinicians to adapt the management of Type 2 diabetes, acco...

Middle East respiratory syndrome coronavirus (MERS-CoV) binds to cellular receptor dipeptidyl peptidase 4 (DPP4) via the spike (S) protein receptor-binding domain (RBD). The RBD contains critical neutralizing epitopes and serves as an important vaccine target. Since RBD mutations occur in different MERS-CoV isolates and antibody escape mutants, cross-neutralization of divergent MERS-CoV strains...

BACKGROUND Adipose tissue (AT) contributes to metabolic dysfunction through imbalanced production of adipokines, including cytokines. Visceral AT in particular is associated with metabolic disorders, indicating a specific secretory status. The relative significance of different human AT depots in adipokine release is not fully known. Further, previous in vitro systems usually included medium co...

type II diabetes5. However, like most proteases, a complete picture of the targets of DPP4 is lacking, which makes it difficult to anticipate metabolic function has prompted the development of a number of small-molecule inhibitors of DPP4, including sitagliptin (Januvia), which was recently approved by the US Food Proteases are enzymes that perform the basic task of cutting up other proteins an...

BACKGROUND AND AIM The number of patients with type 2 diabetes (T2DM) is increasing. Most patients with T2DM are uncontrolled and fail to achieve their target Hba1c. In recent years, newer agents such as SGLT2 inhibitors (SGLT2i) have been approved for clinical use. Though data from clinical trials and sub set analysis of Indian patients in global studies are promising, real world evidence from...

Glucagon-like peptide 2 (GLP-2), secreted by enteroendocrine cells, has several physiological effects on the intestine of monogastric species, including promotion of growth of intestinal epithelium, reduction of epithelial cell apoptosis, and enhancement of intestinal blood flow, nutrient absorption, and epithelial barrier function. The regulatory functions of GLP-2 in the ruminant gastrointest...

In humans, the two main physiologically important incretin hormones are: (1) GLP-1 and (2) GIP. They not only stimulate insulin secretion, but augment insulin stores by upregulating insulin gene expression, and also all the steps in the biosynthesis of insulin. Another attractive facet of incretins is revealed by animal and in vitro studies, which seem to indicate that both these peptides have ...

The voltage-gated potassium channel family (Kv) constitutes the most diverse class of ion channels in the nervous system. Dipeptidyl peptidase 10 (DPP10) is an inactive peptidase that modulates the electrophysiological properties, cell-surface expression and subcellular localization of voltage-gated potassium channels. As a consequence, DPP10 malfunctioning is associated with neurodegenerative ...