The localization of tail-anchored (TA) proteins, whose transmembrane domain resides at the extreme C terminus, presents major challenges to cellular protein targeting machineries. In eukaryotic cells, the highly conserved ATPase, guided entry of tail-anchored protein 3 (Get3), coordinates the delivery of TA proteins to the endoplasmic reticulum. How Get3 uses its ATPase cycle to drive this fund...

Several hybrid-electric vehicle architectures have been commercialized to serve different categories of vehicles and driving conditions. Such architectures can be optimally controlled by switching among driving modes, namely, the power distribution schemes in their planetary gear (PG) transmissions, in order to operate the vehicle in the most efficient regions of engine and motor maps. This pap...

Conventional deadbeat control strategies for permanent magnet synchronous machines (PMSMs) are commonly developed reference frames, however, coupling dynamics affect the performance drive, and rotational transformations required synthesis of final voltage vector (VV). To improve robustness against parameter variations to directly synthesize vector, in this paper a predictive torque flux PMSM is...

Background: Triple-negative breast cancer is the most aggressive subtype. On top of fact that for triple-negative there are no effective therapeutic strategies, it also very often develops resistance to chemotherapy and metastasizes distal organs, condemning patients death. One strategy circumvent insurgence anticancer drug development efficient combinatorial approaches targeting multiple key p...

Manufacturing industries aim to improve product quantity and quality. These trade-off objectives are typically manifested as cycle time reduction motion accuracy improvement. Corner smoothing approaches that reduce the of piecewise linear trajectories proposed in literature. This study tackles two by Pareto-optimal corner with constraints imposed kinematic limits, continuity conditions user-spe...