Colloidal drug carrier is one of the most important entities essentially required for successful transport of loaded drugs. They are drug vectors, which sequester, transport and retain the active drug en route, while they elute or deliver it within or in the vicinity of target. Targeting the drug to the desired site of action would not only improve the therapeutic efficacy but also enable a red...

The evolution of support for the discovery and development of antibacterial (or antibiotic) agents from the larger pharmaceutical companies to the entrepreneur-like small biotechnology companies has been an experiment in the making for the past 15 years. The word 'experiment' is precisely chosen as the outcome is not certain. Many of the antibiotic biotech organizations that were most likely to...

We report the preparation of biodegradable nanoscopic hydrogels and their application for targeted drug delivery. The nanogel is synthesized in a template-free method by photo-crosslinking salt-induced polymer assemblies. With convenient incorporation of targeted lactosyl moieties, the nanogels efficiently deliver doxorubicin to HepG2 cells through receptor-mediated internalization.

We report the delivery of a hydrophobic pesticide, thiamethoxam, by water-soluble nanosized cationic dendrimers that contain hydrophobic dendritic polyesters and peripheral amines, demonstrated by DLS, spectral analysis and ITC. The dendrimer-based nanocarrier can efficiently deliver the pesticide into the live cells and largely increase the cytotoxicity of the drug.

The selective assembly of functionalised fibres produced by wet-spinning into implantable three dimensional contructs presents attractive prospects for the field of medical bionics[1]. In particular, the incorporation of biological factors and large numbers of cells within biocompatible and macroporous fibres is expected to deliver improvements to drug delivery platforms as well as to tissue en...

A therapeutic aptamer-lipid-poly(lactide-co-glycolic acid) hybrid nanoparticle-based drug delivery system was prepared and characterized. This system can co-deliver two different drugs with distinct solubility and different anticancer mechanisms to target cancer cells with high specificity and efficiency.