نتایج جستجو برای: drug hypersensitivity
تعداد نتایج: 610597 فیلتر نتایج به سال:
Delayed drug allergy reactions (DDAR) are potentially fatal. Certain human leukocyte antigen (HLA) alleles have been associated with delayed allergy reactions following the administration of particular drugs. Examples are HLA-B*57:01 (abacavir), HLA-B*15:02/HLA-A*31:01 (carbamazepine), and HLA-B*58:01 (allopurinol). Based on the identification of these associations, it may now be possible to pr...
© 2013 The Authors. doi: 10.2340/00015555-1363 Journal Compilation © 2013 Acta Dermato-Venereologica. ISSN 0001-5555 Drug-induced hypersensitivity syndrome (DIHS), also known as drug rash with eosinophilia and systemic symptoms (DRESS), is a severe, adverse drug reaction characterized by skin rash, fever, lymphadenopathy, hepatitis and haematological abnormalities (1, 2). The presence of human ...
Background Placebo-controlled oral drug provocation tests (DPTs) are an important step in drug hypersensitivity diagnosis. Administration of placebo (an inert sostance not detectable from drug) is recommended to avoid psychological influences on the interpretation of DPT results, however actually little is known about how to deal a reaction to placebo and how to go further with the diagnostic p...
Drug-induced hypersensitivity syndrome (DIHS), also known as drug reactions with eosinophila and systemic symptoms, has unique clinical features including fever, generalized rash, lymphadenopathy and extracutaneous organ involvements. During the disease course, human herpesvirus (HHV)-6 reactivation is frequently (60%<) observed in association with unfavorable outcomes. We recently noticed a tr...
Drug hypersensitivity reactions (DHRs) are the adverse effects of drugs, taken at a dose which is tolerated by normal subjects, which clinically resemble allergy. There are few true epidemiological data on DHRs. The available information requires a cautious interpretation because the pathogenic mechanism has not been demonstrated by diagnostic tests. Both underand over-diagnosis must be taken i...
Results Ninety patients were evaluated, 54 male, with a median age of 6 years. Personal history of atopy was reported in 65 and previous DHR in 9. Cutaneous manifestations were observed in 86 – urticaria and/or angioedema in 71 and macular or maculopapular exanthema in 15. Other symptoms reported were: respiratory (25), gastrointestinal (8), cardiovascular (5). The interval between dose and rea...
Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a common symptom. Here, we demonstrate that the onset of cold hypersensitivity precedes tactile allodynia in a model of partial nerve injury, and this temporal divergence was associated with major differences in global ...
We evaluated the prevalence of and risk factors for hypersensitivity reactions related to carboplatin, which is commonly used to treat gynecological malignancies. All women with pathologically documented ovarian, fallopian tube, or primary peritoneal cancer treated with carboplatin alone or a carboplatin-based combination chemotherapy regimen at a single hospital between January 2006 and Decemb...
statement of the problem dental gloves are worn to protect dental care providers from contamination during contact with mucus membranes, blood and saliva. the prevalence of latex allergy has progressively increased due to the widespread use of protective disposable wears, especially latex gloves, among health care workers (hcw) in the past decade. the prevalence of latex allergy among hcw of ir...
The present article addresses the advances in the diagnosis and management of drug hypersensitivity reactions that were discussed in the 4th Drug Hypersensitivity Meeting held in Rome in April 2010. Such reactions can be classified as immediate or nonimmediate according to the time interval between the last drug administration and onset. Immediate reactions occur within 1 hour, and nonimmediate...
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