Objective: Previous studies showed that grape seed extract (GSE) is an excellent natural substance with potent antioxidant effect and free radical scavenger. This study aimed to evaluate the effect of GSE on motor dysfunctions and thalamic local Electroencephalography (EEG) frequency bands' powers in rats with Parkinson's disease (PD). Materials and Methods: In this study 8 µg 6-hydroxydopamin...

Introduction: Orexin-containing neurons exist in the lateral hypothalamic region, sending their projections toward mesolimbic regions such as the Ventral Tegmental Area (VTA). Methods: In the current study, a Reinstatement model is used to examine the effects of intra-VTA administration of SB334867 as an Orexin-1 Receptor (OX1R) antagonist on drug priming- and Forced Swim Stress (FSS)-induced ...

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe drug-induced adverse fever, cutaneous eruptions, hematological abnormalities, organ dysfunction, reactivation of human herpesvirus 6 (HHV-6). Although rapid diagnosis necessary for the management DIHS/DRESS, it difficult to distinguish early phase DIHS/DRESS from other drug erup...

This study examined the influence of juggling training on mental rotation ability in children with spina bifida. Children between the ages of 8 and 12 solved a chronometric mental rotation test. Half of the children received juggling training (EG) over an 8 week time period; the other half did not receive training (CG). Afterwards, all participants completed the mental rotation test again. Chil...

purpose: to evaluate all cases of drug induced angle closure glaucoma cases who presented to feiz hospital, isfahan during 2008-2010. case report: in this retrospective case series, we present 7 cases of drug induced angle closure glaucoma after administration of topiramate. all patients were female. the average age of patients was 33.28 years old (ranging from 19 to 44). with sufficient cornea...

INTRODUCTION Standard treatment duration for drug-susceptible tuberculosis (TB) treatment is 6 months. Treatment duration is often extended-and for various different reasons. The aim of this study was to determine the prevalence and to assess risk factors associated with extended TB treatment. METHODS A cross-sectional study was conducted. Data including demographic, clinical, radiological an...

The study aimed to investigate the protective mechanisms of substance Darmonal and phytin compounds in experimental model acute toxic drug-induced hepatitis caused by paracetamol rats. material methods research was carried out on white outbred rats both sexes weighing 140-200 g. Drug-induced liver damage reproduced introduction into stomach dose 500 mg/kg for 2 days. test Darmonal, Fitin-C refe...

Objective: This study was aimed to examine the antinociceptive and anti-inflammatory effects of Urtica dioica leaf extract in animal models. Materials and Methods: Hydroalcoholic extract of the plant leaves was prepared by percolation method. Male Swiss mice (25-35 g) and male Wistar rats (180-200 g) were randomly distributed in control, standard drug, and three experimental groups (n=6 in each...

Induced clindamycin resistance poses a major problem for the use of this drug to treat staphylococcal infections. An infectious etiology is often implicated in presence CoNS clinical specimens. A total 183 isolates Staphylococci spp. recovered from different specimens were studied. coagulase test was done select negative Staphylococci, and they confirmed by conventional microbiological techniqu...