conclusions there is a need to train health staff, and the community, concerning preventive measures, treatment, and reducing harm for substance drug users. results among 402 idus patients, a large amount of them were male, single, and younger than 39 years. regarding psychotic and somatic symptoms caused by methadone therapy, most of the participants had no problem with methadone maintenance t...

Therapeutic indications and drug side-effects are both measureable human behavioral or physiological changes in response to the treatment. In modern drug development, both inferring potential therapeutic indications and identifying clinically important drug side-effects are challenging tasks. Previous studies have utilized either chemical structures or protein targets to predict indications and...

helicobacter pylori ( h. pylori ) infection is currently recognized as the major cause of chronic active gastritis, peptic ulcer disease and mucosa associated lymphoid tissue (malt) lymphoma and carcinoma of the stomach. eradication of the infection will prevent the recurrence of the majority of such diseases. different combined treatments have been tried in iran for eradication of h. pylori , ...

The need for drugs with fewer side effects cannot be overemphasized. Today, most drugs modify the actions of enzymes, receptors, transporters and other molecules by directly binding to their active (orthosteric) sites. However, orthosteric site configuration is similar in several proteins performing related functions and this leads to a lower specificity of a drug for the desired protein. Conse...

BACKGROUND AND PURPOSE Topiramate (TPM) is a sulfa-derivative monosaccharide that is used mainly for treating epilepsy and preventing migraine. Within the gamut of side effects attributable to this drug, ophthalmologic manifestations are of crucial importance. In this study, for the first time, the aim was to provide a systematic literature review regarding this issue. METHODS For the time pe...