The cancer drug imatinib inhibits the tyrosine kinases c-Abl, c-Kit, and the PDGF receptor. Imatinib is less effective against c-Src, which is difficult to understand because residues interacting with imatinib in crystal structures of Abl and c-Kit are conserved in c-Src. The crystal structure of the c-Src kinase domain in complex with imatinib closely resembles that of Abl*imatinib and c-Kit*i...

The P-glycoprotein (P-gp) drug pump (ABCB1) has two transmembrane domains and two nucleotide-binding domains (NBDs). Coupling of the drug-binding sites in the transmembrane domains to the NBDs occurs through interaction of the intracellular helices (IHs) with residues in the NBDs (IH1/IH4/NBD1 and IH2/IH3/NBD2). We showed previously that cross-linking of cysteines in IH3 and IH1 with a short cr...

Mastitis is known as the most common disease syndrome in the dairy industry. Treating mastitic lactating animals with antibiotics is a veterinary practice to cure the disease. However, the antibiotic used may persist in the milk for a period of time depending on drug selected, dosage applied, route administered, body weight of the animal treated, etc. Antibiotic residues in milk are of great co...

kumasi, sekondi-takoradi, and accra are the major recipients of agricultural commodities or productions in ghana, primarily due to their population and ready markets. to ensure food security, meet food demands, and mitigate the threats posed by pests and diseases, pesticides are used when cultivating vegetables and fruits in ghana. the present study has been conducted to assess the concentratio...

BACKGROUND MMP-13, a zinc dependent protease which catalyses the cleavage of type II collagen, is expressed in osteoarthritis (OA) and rheumatoid arthritis (RA) patients, but not in normal adult tissues. Therefore, the protease has been intensively studied as a target for the inhibition of progression of OA and RA. Recent reports suggest that selective inhibition of MMP-13 may be achieved by ta...

organophosphorous (op) pesticides are used frequently in agriculture, particularly in asian countries over the past decades. poisoning by these agents, either as acute or chronic in these nations, is a serious health problem. op pesticides residue in fruits and vegetables that may not induce early clinical features, could also affect the human health. therefore, medical and health professionals...

nanoparticles of silver were treaeted as clinical trials in some broiler farms for its disinfecting characters in 4 broiler farms during growing period. the nanosilver were used orally and inhalatory in amount of 2 -4 ppm and 40 ppm respectively. some samples of breast muscle, femora muscle, heart, gizzard, liver, skin, spleen, lung, kidney and cloacal feces were collected randomly in slaughter...

The insecticidal properties of many anthelmintics pose a risk to dung fauna through the effects of drug residues in dung on the activity, oviposition and development of dung-dwelling invertebrates. Reductions in dung fauna numbers can inhibit dung degradation, which may impact biodiversity and nutrient cycling on farms. A simulation model was created to predict the impact of antiparasitic drugs...

Veterinary drug residues of common food (milk, meat) have posed serious threats to the environment and human health, making quality safety agricultural, livestock, aquatic products increasingly prominent. With widespread use veterinary drugs requirements for safety, it has become urgent detect in animal-derived foods. So far, few studies systematically reviewed progresses, challenges, future di...