نتایج جستجو برای: drug response
تعداد نتایج: 1492538 فیلتر نتایج به سال:
One cancer cell line is believed to be composed of numerous clones with different drug sensitivity. We sought to investigate the difference of drug-response pattern in clones from a cell line or from a single cell. We showed that 22 clones derived from 4T1 cells were drastically different from each other with respect to drug-response pattern against 11 anticancer drugs and expression profile of...
Recent research in pharmacogenomics has inspired our hope to predict drug response by linking it with DNA information extracted from the human genome. However, many genetic models of drug response do not incorporate biochemical principles of host-drug interactions, limiting the effectiveness of the predictive models. We argue that functional mapping, a computational tool aimed at identifying ge...
Breast cancer patients have different responses to chemotherapeutic treatments. Genes associated with drug response can provide insight to understand the mechanisms of drug resistance, identify promising therapeutic opportunities, and facilitate personalized treatment. Estrogen receptor (ER) positive and ER negative breast cancer have distinct clinical behavior and molecular properties. However...
background in patients with chronic hepatitis c, triple drug regimens containing a protease inhibitor, peginterferon and ribavirin were found to significantly increase sustained virologic response rates compared to dual drug regimen containing pegylated interferon and ribavirin, especially in genotype 1. objectives in turkey, telaprevir has been used since march 2013. we aimed to evaluate resul...
. Substance use among teenagers appears to be more a function of peer approval and peer drug use. This study examined the relationship between adolescents’ self-derogation and their responses to Peers’ Approval of Drug Abuse (PADA) among male secondary school students. In this study, 3000 students 7 th to the 9 th grade secondary schools completed a sel...
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