Purpose: Lovastatin is poorly water soluble drug. It should be come into the BCS II drug. So oral bioavailability of lovastatin is less (50%). To develop novel dosage foam of the self-microemulsifying drug delivery systems (SMEDDS) for the lovastatin. Methods: Before the formulation of SMEDDS, solubility study was performed in different exicipients and select exicipients on basis of solubility ...

PURPOSE Nanosuspension in drug delivery is known to improve solubility, dissolution and eventually bioavailability of the drugs. The purpose of the study was to compare particle size of nanosuspensions prepared by the first generation approach and H96 approach and to evaluate the effectiveness of H96 approach. METHODS The nanosuspension of aprepitant was prepared by HPH and H96 approach. The ...

Solid dispersions traditionally have been used as effective methods to improve the dissolution properties and bioavailability of poorly water-soluble drugs. Furosemide a loop diuretic belonging to Biopharmaceutical Classification System (BCS) Class IV, has very poor water solubility. The aim of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug, ...

Atorvastatin is a BCS class II lipid lowering agent. It is insoluble in aqueous solution of pH 4 and below; it is very slightly soluble in water and pH 7.4 phosphate buffer. In the present investigation an attempt has been made to enhance solubility and dissolution of poorly soluble drug by formulating self microemulsifying drug delivery system (SMEDDS). The solubility of atorvastatin in indivi...

This commentary addresses data quality in equilibrium solubility measurement in aqueous solution. Broadly discussed is the “gold standard” shake-flask (SF) method used to measure equilibrium solubility of ionizable drug-like molecules as a function of pH. Many factors affecting the quality of the measurement are recognized. Case studies illustrating the analysis of both solution and solid state...

Prednisolone is an analgesic and anti-inflammatory drug. It possesses poor aqueous solubility and has irritant effects on stomach mucosa. In order to modulate its gastric side effect and increase aqueous solubility, physical mixture and solid dispersion of prednisolone were prepared with skimmed milk. In this study, anti-inflammatory and analgesic effects of these formulations were investigated...

Prednisolone is an analgesic and anti-inflammatory drug. It possesses poor aqueous solubility and has irritant effects on stomach mucosa. In order to modulate its gastric side effect and increase aqueous solubility, physical mixture and solid dispersion of prednisolone were prepared with skimmed milk. In this study, anti-inflammatory and analgesic effects of these formulations were investigated...

We report a study of nanoribbons of quercetin, a phase I clinical trial anticancer drug, and their inhibitory effects on cancer cell proliferation. Novel quercetin nanoribbons have been prepared by atmospheric pressure physical vapor deposition (PVD). The nanostructures have been characterized by optical microscopy, scanning electron microscopy, transmission electron microscopy, and Raman spect...

The present work was aimed to design and develop self-nanoemulsifying drug delivery systems (SNEDDS) with the objective to overcome the problems associated with the delivery of talinolol, a hydrophobic and poorly bioavailable drugs having pH dependant solubility. The solubility of talinolol in various oils, surfactants, cosurfactants and aqueous phases were determined to identify and select the...