Experience with management of drug-packers (mules) is variable among different centres. However, despite a recorded increase in drug trafficking in general, as yet, no unified, clear guidelines exist to guide the medical management of those who only occasionally encounter these individuals. We describe our recent experience with this growing problem and discuss the most salient points concernin...

Alzheimer's disease (AD), the most common neurodegenerative disorder, is the leading cause of dementia. Neuritic plaque, one of the major characteristics of AD neuropathology, mainly consists of amyloid β (Aβ) protein. Aβ is derived from amyloid precursor protein (APP) by sequential cleavages of β- and γ-secretase. Although APP upregulation can promote AD pathogenesis by facilitating Aβ product...

Boys and LGBTQ youth, especially those who go missing from home, have recently started to appear in mainstream anti-trafficking discourse as a group of children are peculiarly vulnerable human trafficking. This paper reports findings research with Jamaicans experienced various forms violence exploitation children. Our data is consistent the claim that boys amongst experience policy makers often...

The international drug trade and the power of drug cartels have perplexed both analysts and policy makers for years. As drug production and trade grow, cartels have climbed to unthinkable heights of power and, in some cases, have crippled governments. This study explores this problem and attempts to answer the predominant question raised: why do states struggle to eradicate such powerful govern...

Exchange factors for ARF GTPases (ARF-GEFs) regulate vesicle trafficking in a variety of organisms. The Arabidopsis protein GNOM is a brefeldin A (BFA) sensitive ARF-GEF that is required for the proper polar localization of PIN1, a candidate transporter of the plant hormone auxin. Mutations in GNOM lead to developmental defects that resemble those caused by interfering with auxin transport. Bot...

Статья посвящена вопросам обучения английской терминологии на занятиях по иностранному языку в образовательных организациях системы МВД России. Подчеркивается необходимость учета приоритетного профиля подготовки будущих полицейских. Дается обзор существующих данный момент толковых (терминологических) словарей, содержание которых составляет лексика, объединенная рамках т.н. наркотематики. Привод...

BACKGROUND This ethnographic study was conducted along the U.S.-Mexico border, the centre of the western hemispheric illicit drugs trade. It examines factors that encouraged or discouraged drug traffickers to "get out of the game" (a common slang reference to leaving the drug business). METHODS In-depth, life history interviews were conducted of thirty ex-traffickers in the El Paso/Ciudad Juá...

Manganese (Mn) protects cells against lethal doses of purified Shiga toxin by causing the degradation of the cycling transmembrane protein GPP130, which the toxin uses as a trafficking receptor. Mn-induced GPP130 down-regulation, in addition to being a potential therapeutic approach against Shiga toxicosis, is a model for the study of metal-regulated protein sorting. Significantly, however, the...

This paper focuses on some of the methods and techniques used by law enforcement authorities to identify suspects, crimes, the manner in which they were committed and the evidence necessary for proving the criminal activity. The study mentiones the sensitive character of these means and methods by considering that they may often violate fundamental human rights and freedoms.

Long-standing federal drug-control policy aims to reduce the flow of narcotics into USA, in part by intercepting cocaine shipments en route from South American production regions North consumer markets. Drug interdiction efforts operate over a large geographic area, containing complex drug trafficking networks dynamic environment. The extant models operations research and location science liter...