background the treatment of posterior eye diseases is always challenging mainly due to inaccessibility of the region. many drugs are currently delivered by repeated intraocular injections. objectives the purpose of this study was to investigate the potential applications of natural triglycerides as alternative carriers to synthetic polymers in terms of drug release profile and also biocompatibi...

OBJECTIVES To use primary care electronic health records (EHRs) to evaluate prescriptions and inappropriate prescribing in men and women at age 100. DESIGN Population-based cohort study. SETTING Primary care database in the United Kingdom, 1990 to 2013. PARTICIPANTS Individuals reaching the age of 100 between 1990 and 2013 (N = 11,084; n = 8,982 women, n = 2,102 men). MEASUREMENTS Main ...

Cyclooxygenase (COX)-2-specific inhibitors were developed to circumvent the gastrointestinal toxicity of non-specific non-steroidal anti-inflammatory drugs while maintaining efficacy. However, the higher acquisition cost of COX-2-specific inhibitors has resulted in the implementation of a programme for cost containment in the Ontario public drug program. This programme consists of limited use (...

Schizophrenia is a chronic debilitating major psychiatric disorder which may require life long treatment. Treatment of such patients at an early stage may prevent loss of morbidity, mortality and productivity. Till date, pharmacotherapy remains the cornerstone of treatment in such patients . Serendipitous discovery of chlorpromazine and lithium in the fifties brought about a revolution in the f...

The objective of this study was to determine the prevalence of Potentially Inappropriate Medication (PIM) use and associated factors, as well as the prevalence of Prescribing Omissions (PO). A cross-sectional study was conducted in a philanthropic Brazilian nursing home involving 46 individuals aged 60 years or older. The following information was collected from medical records and drug prescri...

Drug treatment courts (DTCs), which are judicially mandated treatment alternatives to the incarceration of illicit drug offenders, were introduced in Canada in late 1998. Recent announcements from the federal government suggest that the drug treatment court model will continue to operate and expand in a number of Canadian jurisdictions. Two major evaluations of these programs--in Vancouver and ...