From teenagers dying from heroin overdoses to crime tied to Vicodin and OxyContin addiction to road fatalities in which sedatives and muscle relaxants are involved, 20,000 deaths in the United States in 2014 were attributed to problems associated with narcotics and prescription drug use. Our author, whose research involves the neurobiological basis of drug addiction, traces the history and evol...

Opioid abuse is a growing global problem. Current therapies for opioid target withdrawal symptoms and have several adverse side effects. There are no treatments to address opioid-induced neural adaptations associated with addiction. Preclinical research demonstrates interactions between the endogenous cannabinoid systems, suggesting that cannabinoids may be used treat addiction dependence. The ...

conclusions performing htp can improve hopefulness and symptoms of patients, specially addicted ones. in addition, it can prevent substance abusers from returning to drugs and leaving the treatment period unfinished. results the results showed that f value of mean scores in depression and hope post-tests of the experimental and control groups are 24.94 and 25.73, respectively, which are signifi...

background research shows that parents have an immense influence over their children’s behavior during adolescence. adolescents who grow up with parents who are addicted to drugs and alcohol are more likely to turn to self-destructive behaviors such as suicide attempts. because addiction in iran is a primarily masculine phenomenon and in traditional iranian culture, the father is responsible fo...

Chronic orofacial pain is common and complex, and it is frequently accompanied by comorbidities. These comorbidities include not only pain that may occur in other parts of the body (eg, neck pain, fibromyalgia, irritable bowel) but also psychosocial disorders such as depression, mood dysfunction, and sometimes substance use disorders involving drugs prescribed to manage the pain condition. For ...

due to special conditions of iran; i.e., neighboring to major centers of drug production in afghanistan during the last few decades, it was the passageway of the drug to europe. moreover, because of appropriate context of social, economic and cultural situations, there was an increased addiction and drug trafficking in iran. it is obvious that a lot of people would be involved directly and indi...

Drug abuse and addiction cause widespread social and public health problems, and the neurobiology underlying drug actions and drug use and abuse is an area of intensive research. Drugs of abuse alter synaptic transmission, and these actions contribute to acute intoxication as well as the chronic effects of abused substances. Transmission at most mammalian synapses involves neurotransmitter acti...

Drug addiction is characterized by compulsive drug-seeking and drug-taking, and a high propensity for relapse. Although the brain regions involved in regulating addiction processes have long been identified, the ways in which individual cell types govern addiction behaviors remain elusive. New technologies for modulating the activity of defined cell types have recently emerged that are allowing...

Drug addiction is a chronically relapsing disorder characterized by the compulsive desire to use drugs and a loss of control over consumption. Cannabidiol (CBD), the second most abundant component of cannabis, is thought to modulate various neuronal circuits involved in drug addiction. The goal of this systematic review is to summarize the available preclinical and clinical data on the impact o...

Drug addiction is a chronic relapsing disorder for which research has been dedicated to understand the various factors that contribute to development, loss of control, and persistence of compulsive addictive behaviors. In this review, we provide a broad overview of various theories of addiction, drugs of abuse, and the neurobiology involved across the addiction cycle. Specific focus is devoted ...