Lymphopenic conditions lead to expansion of memory-like T cells (TML), which develop from naïve T cells by spontaneous proliferation. TML cells are often increased in the elderly population, AIDS patients, and patients recovering from radio- or chemotherapy. At present, it is unclear whether TML cells can efficiently respond to foreign antigen and participate in antiviral immunity. To address t...

Naive T lymphocytes acquire a phenotype similar to Ag-experienced memory T cells as a result of proliferation under lymphopenic conditions. Such "memory-like" T (T(ML)) cells constitute a large fraction of the peripheral T cell pool in patients recovering from T cell ablative therapies, HIV patients under highly active antiretroviral therapy, and in the elderly population. To generate a model t...

As an immunotoxin, diphtheria toxin has been widely used in gene therapy and gene function assays for its roles in protein synthesis inhibition, and the aim of our study is to set up a nonintegrating lentiviral system for specific expression of diphtheria toxin A (DTA) used in cancer gene therapy.Here, we established a lentiviral system that could coordinately express fluorescent protein and DT...

It is well known that for a regular tree language it decidable whether or not can be recognized by deterministic top-down automaton (DTA). However, the computational complexity of this problem has been studied. We show given bottom-up decided in quadratic time its DTA. Since there are finite languages cannot DTAs, we also consider unions DTAs and here, definability within automata time.

The research on affinity between drugs and targets (DTA) aims to effectively narrow the target search space for drug repurposing. Therefore, reasonable prediction of affinities can minimize waste resources such as human material resources. In this work, a novel graph-based model called DSAGLSTM-DTA was proposed DTA prediction. is unlike previous drug-target model, which incorporated self-attent...

Schiff bases derived by condensation reaction from cinnamaldehyde and/or -bromocinnamaldehyde and 4-(4-aminophenylsulfonyl)benzenamine are reported and characterized based on elemental analyses, IR, H NMR, C NMR and thermal analysis (TG/DTA). 1 13

Antibody-directed liposomes (immunoliposomes) are frequently used for targeted drug delivery. However, delivery of large biotherapeutic molecules (i.e. peptides, proteins, or nucleic acids) with immunoliposomes is often hampered by an inefficient cytosolic release of entrapped macromolecules after target cell binding and subsequent endocytosis of immunoliposomes. To enhance cytosolic drug deliv...