The biosynthesis of isopentenyl diphosphate (IPP) from either the mevalonate (MVA) or the 1-deoxy-d-xylulose 5-phosphate (DXP) pathway provides the key metabolite for primary and secondary isoprenoid biosynthesis. Isoprenoid metabolism plays crucial roles in membrane stability, steroid biosynthesis, vitamin production, protein localization, defense and communication, photoprotection, sugar tran...

Tiny nanoparticles of dexamethasone palmitate (DXP) were designed as transparent suspensions for intravitreal administration to treat age-related macular degeneration (AMD). The influence three surfactants (PEG-40-stearate and Pluronic block copolymers F68 F127) on size stability was investigated led an optimal formulation based F127 stabilizing DXP nanoparticles. Size measurements TEM revealed...

BACKGROUND Reactions of vaccinia topoisomerase and the tyrosine site-specific recombinase Flp with methylphosphonate (MeP) substituted DNA substrates, have provided important insights into the electrostatic features of the strand cleavage and strand joining steps catalyzed by them. A conserved arginine residue in the catalytic pentad, Arg-223 in topoisomerase and Arg-308 in Flp, is not essentia...

OBJECTIVE To investigate the relationship between motor evoked potential (MEP) response and the severity of motor paralysis, evaluated according to the Korean disability evaluation system in patients with spinal cord injury (SCI). METHODS We analyzed 192 lower limbs of 96 SCI patients. Lower limbs were classified according to their motor scores, as determined by the International Standards fo...

The methylerythritol phosphate (MEP) pathway is an essential metabolic pathway found in malaria parasites, but absent in mammals, making it a highly attractive target for the discovery of novel and selective antimalarial therapies. Using high-throughput screening, we have identified 2-phenyl benzo[d]isothiazol-3(2H)-ones as species-selective inhibitors of Plasmodium spp. 2-C-methyl-D-erythritol...

To explore the effects of qualitative or quantitative changes in walking on motor cortical excitability, a transcranial magnetic stimulation procedure was used to examine the alterations of motor-evoked potential (MEP) amplitude following walking. Eight healthy participants completed a series of two walking tasks on a treadmill at 2 km/h. The ratio of the left stance duration to the right stanc...

This paper proposes the concept of Minimum Executable Pattern (MEP), and then presents a MEP generation method and a MEP-based Deep Web adaptive query method. The query method extends query interface from single textbox to MEP set, and generates local-optimal query by choosing a MEP and a keyword vector of the MEP. Our method overcomes the problem of “data islands” to a certain extent which res...

It has been suggested that the maximum entropy production (MEP) principle, or MEP hypothesis, could be an interesting tool to compute climatic variables like temperature. In this climatological context, a major limitation of MEP is that it is generally assumed to be applicable only for stationary systems. It is therefore often anticipated that critical climatic features like the seasonal cycle ...

Repetitive transcranial magnetic stimulation (rTMS) can induce short-term reorganization of human motor cortex. Here, we investigated the effect of rTMS during relaxation and weak voluntary muscle contraction on motor cortex excitability and hand function. Subjects (n = 60) participated in one of four studies. Single transcranial magnetic stimuli were delivered over the motor area of the first ...

BACKGROUND While there is growing evidence for the efficacy of SM to treat LBP, little is known on the mechanisms and physiologic effects of these treatments. Accordingly, the purpose of this study was to determine whether SM alters the amplitude of the motor evoked potential (MEP) or the short-latency stretch reflex of the erector spinae muscles, and whether these physiologic responses depend ...