The mucosal-dominant variant of pemphigus vulgaris (MPV) is an autoimmune disease characterized by oral mucosal blistering and circulating pathogenic IgG antibodies against desmoglein 3 (Dsg3), resulting in life-threatening bullae erosion formation. Recently, microRNAs (miRNAs) have emerged as promising players the diagnosis prognosis several pathological states. For first time, we identified a...

Darier disease (DD) is a dominantly inherited skin disorder. It characterized by painful and malodourous plaques papules on the of patients. The typical features DD include: acantholysis abnormal keratinization. These histological are due to mutations in gene, ATP2A2, which encodes sarco/endoplasmic reticulum (ER) Ca2+-ATPase isoform 2 (SERCA2), pump ER. This leads malformation desmosomes adher...

Congenital self-healing Langerhans cell histiocytosis (CSHLCH), or Hashimoto-Pritzker disease, is a rare variant of Langerhans cell histiocytosis that was first described in 1973 by Hashimoto and Pritzker.1-5 It presents at birth or in the neonatal period.1-9 Few case series have been published in the literature.1,4,5 However, it is believed that the actual incidence is higher and that many cas...

With the continued development of non-invasive therapies for actinic keratosis such as PDT and immune therapies, the non-invasive diagnosis and monitoring become increasingly relevant. High-definition optical coherence tomography is a high-resolution imaging tool, with micrometre resolution in both transversal and axial directions, enable to visualize individual cells up to a depth of around 57...

Although the histopathogenetic process of keratin pearls is still poorly understood, acceleration of keratinization in squamous cell carcinoma (SCC) cells may represent one possible therapeutic avenue. Based on our histopathological observations, we have hypothesized that SCC cells are keratinized by phagocytosis of extravasated erythrocytes. To confirm this hypothesis, we firstly examined imma...

DWD: Darier-White disease INTRODUCTION Darier-White disease (DWD) is an autosomaldominant skin disease characterized by warty keratotic papules and plaques in a primarily seborrheic distribution. Vegetating papules, erosions, or blisters may sometimes be present. Other findings may include varieties of nail abnormalities, ‘‘cobblestoning’’ of the oral mucosa, filiform keratoderma on the palms a...

Pemphigus vulgaris (PV) is an acquired autoimmune blistering disease characterized by the production of autoantibodies targeting desmosomal cadherins, primarily desmoglein 1 and 3, leading to acantholysis. The etiology PV multifactorial, including genetic susceptibility. This retrospective study aimed evaluate association HLA class II alleles examine impact PV-associated on concentration anti-d...

p38 mitogen activated protein kinase (p38 MAPK) signaling plays a major role in the modulation of immune-mediated inflammatory responses and therefore has been linked with several autoimmune diseases. The extent of the involvement of p38 MAPK in the pathogenesis of autoimmune blistering diseases has started to emerge, but whether it pays a critical role is a matter of debate. The activity of p3...