Drug-induced QT prolongation is a potentially dangerous adverse effect of some medication combinations. When QT prolongation progresses to torsade de pointes, life-threatening or fatal outcomes may result. A 57-year-old man with a history of human immunodeficiency syndrome on abacavir, nevirapine, tenofovir, voriconazole, and methadone presented to the emergency department with a chief complain...

The electrocardiographic and haemodynamic responses to the induction of anaesthesia, followed by laryngoscopy and endotracheal intubation have been studied in a group of 16 untreated hypertensive patients, and a group of 20 patients receiving antihypertensive therapy up to and including the day of operation. The influence of five different induction agents, thiopentone, methohexitone, propanidi...

Background: Significant numbers of patients who undergo major surgery experience postoperative problems, the majority which are preventable. It has been demonstrated that goal-directed therapy, a method for guiding clinicians in administering fluids, vasopressors, and inotropes, reduces mortality complications. However, heart transplant were not exclusively investigated. This study focused on h...

Today, more families are affected by Diabetes Mellitus (DM) disease on account of its continually increasing occurrence. Most patients remain unknown about their health quality or the DM’s risk factors prior to diagnosis. The medical world has witnessed that individuals two different diabetes namely a) Type-1 (T1D), as well b) Type-2 (T2D). As Type 2 affects other organs body, proposed system c...

Progress in the detection and treatment of cancer has led to an impressive reduction in both mortality and morbidity. Due to their mechanism of action, however, conventional chemotherapeutics and some of the newer anti-cancer signaling inhibitors carry a substantial risk of cardiovascular side effects that include cardiac dysfunction and heart failure, arterial hypertension, vasospastic and thr...

Thenacho, H. N. C., Patel, R. G., Singh, S. P., Astley, R., and Parsons, C. G. (1973). Thorax, 28, 448452. Transposition of the great arteries. A review of 37 cases after Mustard's operation. Thirty-seven children with transposition of the great arteries have undergone Mustard's operation in Birmingham Children's Hospital from May 1968 to December 1971. Thirtythree of these had simple transposi...

This study is of a family with a syndrome of atrial fibrillation or flutter with advanced or complete atrioventricular (A-V) block, involving four members in two generations. Less serious arrhythmias were documented in another 15 members (three generations). Inheritance was by autosomal dominance with varying degrees of expression. An atrial biopsy was obtained in one of the members, a 40-year-...

AIM To study the direct correlation between gastric dysrhythmias and in vivo gastric muscle tone. METHODS Five healthy dogs were implanted with 4 pairs of electrodes along the greater curvature, with a strain gauge (SG) being sutured parallel to the distal electrodes (2 cm above the pylorus). Intravenous vasopressin was given to induce gastric dysrhythmia. The percentage of regular slow waves...

One-third of 327 newborn infants referred to the perinatal service of the Hospital for Sick Children during 1975 with suspected cardiopulmonary disorders proved to have nonstructural heart disease. Most of these were term infants with transient tachypnoea or cyanosis who recovered. A history of fetal distress or difficult delivery was commonly associated. The haemodynamic disorder for most was ...

Mutations in over 70 genes now define biological pathways leading to epilepsy, an episodic dysrhythmia of the cerebral cortex marked by abnormal network synchronization. Some of the inherited errors destabilize neuronal signaling by inflicting primary disorders of membrane excitability and synaptic transmission, whereas others do so indirectly by perturbing critical control points that balance ...