There are two solutions to the ageing problem – tactical and strategic. The solution is dampen involution as much possible delay onset slow down progression of age-related pathologies. strategic eliminate per se (and therefore diseases) through elimination prime cause ageing. These approaches discussed. ___________________________________________________________________________________________ ...

After sustained exposure to Mycobacterium leprae, only a subset of exposed individuals develops clinical leprosy. Moreover, leprosy patients show a wide spectrum of clinical manifestations that extend from the paucibacillary (PB) to the multibacillary (MB) form of the disease. This "polarization" of leprosy has long been a major focus of investigation for immunologists because of the different ...

Background & Aims: Duo to clinical use of antibiotics, pseudomonas aeruginosa strains with multiple drugs resistance have significantly increased throughout the world. Betalactamase production is one of the Mechanisms involved in resistance to pseudomonas aeruginosa resulting in many problems in the treatment of infections caused by this bacterium. The aim of this study was molecular analysis o...

During the 1980s and 1990s, Salmonella serotype Enteritidis (SE) emerged as an important cause of human illness in the United States. The rate of SE isolates reported to CDC increased from 0.6 per 100,000 population in 1976 to 3.6 per 100,000 in 1996 (Figure 1). Case-control studies of sporadic infections and outbreak investigations found that this increase was associated with eating raw or und...

septoria tritici blotch (stb), caused by the ascomycete fungus mycosphaerella graminicola (asexual stage: septoria tritici), is one of the most important foliar diseases of wheat. in this research, quantitative expression analysis of five candidate genes for the induction of resistance to stb (pr-1, bsi, msr, per, and ppi) was conducted in the wheat cultivars ‘seri 82’ (susceptible) and ‘fronta...

Recent studies have correlated metabolic diseases, such as metabolic syndrome and non-alcoholic fatty liver disease, with the circadian clock. However, whether such metabolic changes per se affect the circadian clock remains controversial. To address this, we investigated the daily mRNA expression profiles of clock genes in the liver of a dietary mouse model of non-alcoholic steatohepatitis (NA...

The molecular basis for the adaptation of fruit tissues to low oxygen treatments remains largely unknown. RT-PCR differential display (DD) was employed to isolate anoxic and/or hypoxic genes whose expression responded to short, low-oxygen regimes. This approach led to the isolation, cloning, successful sequencing, and bioinformatic analysis of 98 transcripts from Citrus flavedo tissues that wer...

Deciding a patent’s validity is costly, and so is deciding it incorrectly. Judges and juries must expend significant resources in order to reach a patent validity determination that is properly informed by the relevant facts. At the same time, patent validity determinations reached quickly and cheaply may conserve resources today while creating future costs. Wrongly preserving an invalid patent...