Eccrine sweat is secreted onto the skin's surface and is not harmful to normal skin, but can exacerbate eczematous lesions in atopic dermatitis. Although eccrine sweat contains a number of minerals, proteins, and proteolytic enzymes, how it causes skin inflammation is not clear. We hypothesized that it stimulates keratinocytes directly, as a danger signal. Eccrine sweat was collected from the a...

Long tubular excretory duct of the human eccrine sweat gland has been divided by light microscopy into three portions: the initial or coiled portion which is included in the glandular coil, the ascending or straight portion which runs in the dermis toward the epidermis and the terminal or intraepidermal portion which ascends spirally through the epidermis toward the free surface of the skin to ...

Cortisol has long been recognized as the "stress biomarker" in evaluating stress related disorders. Plasma, urine or saliva are the current source for cortisol analysis. The sampling of these biofluids is either invasive or has reliability problems that could lead to inaccurate results. Sweat has drawn increasing attention as a promising source for non-invasive stress analysis. A sensitive HPLC...

Dermoscopy revealed a well-defined, erythematous-pink tumor (Fig. 2A) with prominent, more or less evenly distributed blood vessels, with characteristic cherry blossom images mostly at the periphery of the tumor (Fig. 2B), and pale pink structureless areas (Fig. 2A). With a suspected diagnosis of eccrine poroma, the lesion was excised and the histological findings confirmed the diagnosis. Eccri...