Liposomes have been exploited for pharmaceutical purposes, including diagnostic imaging and drug and gene delivery. The versatility of liposomes as drug carriers has been demonstrated by a variety of clinically approved formulations. Since liposomes were first reported, research of liposomal formulations has progressed to produce improved delivery systems. One example of this progress is stealt...

Phospholipids were isolated from camel milk and identified by using high performance liquid chromatography and gas chromatography-mass spectrometry (GC/MS). Anticancer drug etoposide (ETP) was entrapped in liposomes, prepared from camel milk phospholipids, to determine its activity against fibrosarcoma in a murine model. Fibrosarcoma was induced in mice by injecting benzopyrene (BAP) and tumor-...

objective: this study aimed to evaluate a co-encapsulated pegylated nano-liposome system based on two herbal anti-tumor drugs, silibinin and glycyrrhizic acid, for delivery to a hepatocellular carcinoma (hcc) cell line (hepg2). materials and methods: in this experimental study, co-encapsulated nano-liposomes by the thin layer film hydration method with hepes buffer and sonication at 60% amplitu...

Lipids extracted with chloroform-methanol from red blood cell membranes of 7 PNH and 13 control subjects were used for the preparation of liposomes, which were then examined with the reactive lysis test. PNH liposomes lysed to a higher extent than control liposomes as indicated by the higher dilution of the limiting complement reagent that was necessary to lyse 50% of the PNH liposomes. A simil...

Liposomes are one of the most well-known and promising nanoscale drug delivery systems. Liposomal medicinal products successfully used in clinical practice for cardiovascular, oncological, dermatological, other indications. The development liposomes their widespread implementation relevant tasks. aim study was to summarise analyse scientific data regarding structure, composition, classification...

background: dna vaccines are third generation vaccines which have made promises to combat infectious diseases. cationic liposomes are used as effective delivery systems for dna vaccines to generate stronger immunity. objective: encapsulation of pcdna3.1+pa plasmid, encoding protective antigen (pa) of bacillus anthracis (b. anthracis) into cationic liposomes, and evaluation of its effect on spec...

A lipid named DCPA was synthesized under microwave-assisted heating. possesses a pyridine betaine, hydrophilic group that can be complexed with water through hydrogen bonding (DCPA-H2O). DCPA-H2O liposomes became protonated relatively fast already at pH<6.8, due to the high HOMO binding energy of DCPA-H2O. In murine models, had longer blood circulation times than natural DPPC or cationic DCPM l...

In this study, a novel NGR (Asn-Gly-Arg) peptide-modified liposomal brucine was prepared by using spray-drying method. The surface morphology of the liposomes, encapsulation efficiency and particle size were investigated. The data showed that the addition of NGR did not produce any significant influence on brucine liposomes in terms of particle size or zeta potential. In addition, after 3 month...