OBJECTIVE To assess the relation between serum leptin levels and lipid profile in women with pre-eclampsia and to evaluate their atherogenic role in the pathophysiology of pre-eclampsia. METHODS This was a comparative cross-sectional study, carried out in the Department of Physiology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre (JPMC), in collaboration with the depart...

BACKGROUND The Finnish Pre-eclampsia Consortium (FINNPEC) case-control cohort consisting of 1447 pre-eclamptic and 1068 non-pre-eclamptic women was recruited during 2008-2011 to study genetic background of pre-eclampsia and foetal growth. Pre-eclampsia was defined by hypertension and proteinuria according to the American College of Obstetricians and Gynecologists (ACOG) 2002 classification. The...

BACKGROUND The maternal mortality ratio of Uganda is still high and the leading causes of maternal mortality are postpartum haemorrhage (PPH), severe pre-eclampsia and eclampsia. Criteria-based audit (CBA) is a way of improving quality of care that has not been commonly used in low income countries. This study aimed at finding out the quality of care provided to patients with these conditions a...

OBJECTIVE To investigate the predictive value of the combination of first-trimester serum placental protein 13 (PP13), uterine artery Doppler pulsatility index (PI) and pulse wave analysis (augmentation index at a heart rate of 75 beats per min (AIx-75)), and to evaluate concurrent and contingent strategies using this combination for assessing the risk of pre-eclampsia in high-risk women. MET...

Background and Purpose—Women who develop pre-eclampsia in pregnancy are at increased risk of cardiovascular disease. The offspring from pregnancies complicated by pre-eclampsia have higher blood pressures during childhood, but little is known about their long-term health. We hypothesized that pre-eclampsia would lead to an increased risk of cardiovascular disease in the offspring. Methods—We tr...

Background: Our objective was to study the presentation and determinants of maternal outcome . Research Methodology: A cross sectional study was designed and data was collected over six months from 1-1-03 to 30-6-03 at a tertiary care hospital, Postgraduate Medical Institute, Lady Reading Hospital Peshawar. All cases of eclampsia (n = 50) admitted to Gynae “A” unit during the study period were ...

acomparative study of low dose magnesium sulphate regime and pritchard regime for imminent eclampsia and eclampsia. Aim: To Study the effectiveness, side effects and maternal and perinatal outcome using low dose MgSO4 in comparison with the standard Pritchard regimen. Objective: 1) To study the efficacy of low dose MgSo4 regime for control of convulsions in eclampsia and as seizure prophylaxis ...

OBJECTIVE Pre-eclampsia, which is a major cause of perinatal and maternal morbidity and mortality, is thought to be due to impaired perfusion of the placenta. There is contradictory evidence that the administration of low-dose aspirin may provide effective prophylaxis against the subsequent development of pre-eclampsia. In this study we tested the hypothesis that in women identified as being at...

OBJECTIVE To develop a practical evidence based list of clinical risk factors that can be assessed by a clinician at ≤ 16 weeks' gestation to estimate a woman's risk of pre-eclampsia. DESIGN Systematic review and meta-analysis of cohort studies. DATA SOURCES PubMed and Embase databases, 2000-15. ELIGIBILITY CRITERIA FOR SELECTING STUDIES Cohort studies with ≥ 1000 participants that evalua...

An association between pre-eclampsia and febrile convulsions has been reported, but the association may not be causal. We compared the risk of febrile convulsions in 14 974 children who had been exposed to pre-eclampsia in fetal life with that of 39 210 unexposed children. Children exposed to pre-eclampsia had a slightly increased risk of febrile convulsions, but the association was apparently ...