نتایج جستجو برای: efavirenz
تعداد نتایج: 2276 فیلتر نتایج به سال:
Abstract Density functional theory (DFT) was performed in the gas phase to investigate tautomerization and transitions efavirenz. The amide imidic tautomers' geometrical parameters are using B3LYP/6-31++G** M06-2X/ cc-pVTZ (-F). results showed that tautomer is more stable than phase. non-linear optical (NLO) properties of tautomers computed. Interestingly, forms may be an attractive compound en...
Article history: Received 11 October 2016 Accepted 11 October 2016 Available online 13 October 2016 formation on the impact of different ART regimens on inflammatory biomarkers linked with mortality remains, however, very limited. Recently, integrase inhibitors have shown to improve inflammation or immune activation markers when compared to non-nucleoside reverse transcriptase inhibitors. In pa...
L’éfavirenz est un inhibiteur sélectif non nucléosidique de la transcriptase inverse du virus l’immunodéficience humaine type 1 (VIH-1) se caractérisant par index thérapeutique étroit et une forte variabilité inter-individuelle dans ses paramètres pharmacocinétiques. L’objectif ce travail était développer valider méthode rapide simple dosage plasmatique l’éfavirenz chromatographie liquide haute...
Although there is a presumed drug-drug interaction between itraconazole and nonnucleoside reverse-transcriptase inhibitors, the medical literature lacks such documentation. We describe a drug-drug interaction between itraconazole and efavirenz in a patient with disseminated histoplasmosis and acquired immunodeficiency syndrome (AIDS). The drug combination resulted in persistently elevated urina...
A highly enantioselective and practical synthesis of the HIV-1 reverse transcriptase inhibitor efavirenz (1) is described. The synthesis proceeds in 62% overall yield in seven steps from 4-chloroaniline (6) to give efavirenz (1) in excellent chemical and optical purity. A novel, enantioselective addition of Li-cyclopropyl acetylide (4a) to p-methoxybenzyl-protected ketoaniline 3a mediated by (1...
A 23-year-old human immunodeficiency virus (HIV)-infected Indian woman was admitted to a tertiary care hospital with generalized erythematosus rash all over her body with difficulty in swallowing for the previous 3 days. She also presented with swelling of the lips and redness of both eyes along with nausea, anorexia, slight headache, and fever, which appeared immediately after the initiation o...
Efavirenz is a drug with an absorption window. Its oral bioavailability is 40-50%. The aim of this work was to formulate solid self-emulsifying drug delivery system to improve the solubility and bioavailability of efavirenz. Solubility of Efavirenz was determined in various vehicles like oils, surfactants and co surfactants. Which, upon dilution with aqueous media, spontaneously form fine oil i...
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