A new aromatic bisguanylhydrazone derivative, 4,4'-diacetyldiphenyl-urea-bis(guanylhydrazone), markedly prolonged the survival of DBA/2Ha and DBA/2J mice inoculated i.p. or s.c. with leukemia L1210. Drug-induced 50-day cures of leukemic mice occurred with a higher incidence in DBA/2Ha than in DBA/2J mice, and in female than in male mice. The drug was active by parenteral but not by oral route o...

OBJECTIVE Greater accumulation of visceral fat is strongly linked to risk of cardiovascular disease. However, elevated waist circumference by itself does not always identify individuals with increased visceral fat. RESEARCH DESIGN AND METHODS We examined 375 subjects with type 2 diabetes from the CHICAGO cohort for presence of hypertriglyceridemic waist phenotype (waist circumference >90 cm i...

DTW Barycenter Averaging (DBA) has proven to be a useful tool for calculating consensus sequences, but it has not yet been applied to real electroencephalography (EEG) data. This study tests DBA on real EEG sequences using the modification proposed by Kotas et al. (2015), and proposes several further modifications to the initial sequence selection process to improve the method’s efficacy for EE...

OBJECTIVE The purpose of this study was to verify the noise level at a PICU. METHODS This prospective observational study was performed in a 10 bed PICU at a teaching hospital located in a densely populated district within the city of São Paulo, Brazil. Sound pressure levels (dBA) were measured 24 hours during a 6-day period. Noise recording equipment was placed in the PICU access corridor, n...

This paper assesses the waking effectiveness of strobe lights and pillow and bed shakers as smoke alarm warning devices and compares them to an auditory signal. The signals were activated at increasing intensity levels during slow wave (deep) sleep in two groups, (i) 38 adults aged 18-77 years with hearing loss of 2570 dBA in both ears, and (ii) 32 young adults aged 18 -26 years impaired with a...

Several structurally related anisidine and dibenzanthracene isomers were evaluated for genotoxic effects in the somatic w/w+ assay of Drosophila melanogaster employing insecticide-susceptible (IS) and insecticide-resistant (IR) tester strains. In addition, and in order to find whether or not at the genetic level a regulatory effect is found, crosses between ISxIR strains and IRxIS strains were ...

Submarine groundwater discharge (SGD) can have a profound influence on marine environments and elemental biogeochemical cycles in coastal waters. We explored the feasibility of using Ba/Ca ratios benthic foraminiferal shells as proxy SGD. Dissolved barium (DBa) displayed enrichment behavior bottom waters indicating that SGD is major DBa source Changjiang (Yangtze) Estuary. Foraminifera lived wi...

Manipulations of rearing conditions have been used to examine the effects of early experience on adult behavior with varying results. Evidence suggests that postnatal days (PND) 15-21 are a time of particular susceptibility to environmental influences on anxiety-like behavior in mice. To examine this, we subjected C57BL/6J and DBA/2J mice to an early handling-like procedure. Pups were separated...

Objective. Determination of the effect of dentin bonding agent (DBA) on the prevention of tooth discoloration produced by mineral trioxide aggregate (MTA). Methods. 50 teeth were endodontically treated and after removal of 3 mm of obturating materials were divided into five groups. In white MTA (WMTA) and grey MTA (GMTA) groups, these materials were placed in root canal below the orifice. In DB...