The in vivo formation of beta-pleated protein aggregates underlies a number of fatal neurodegenerative disorders, such as Alzheimer disease. Since molecular mechanisms of protein misfolding and aggregation remain poorly understood, this has been calling for many diverse biophysical tools capable of addressing different dynamic and conformational aspects of the phenomenon. The two model polypept...

Bias-induced oxygen ion dynamics underpins a broad spectrum of electroresistive and memristive phenomena in oxide materials. Although widely studied by device-level and local voltage-current spectroscopies, the relationship between electroresistive phenomena, local electrochemical behaviors, and microstructures remains elusive. Here, the interplay between history-dependent electronic transport ...

In several recent publications 1-6 we have shown experimentally that the acidic groups present in collodion are the primary cause of its electrochemical activity in solutions of strong inorganic electrolytes. The surface concentration of these acidic dissociable groups is assumed to determine the degree of electrochemical activity of any given collodion sample. The abundance of these groups var...

Nanoporous gold (np-Au), because of its high surface area-to-volume ratio, excellent conductivity, chemical inertness, physical stability, biocompatibility, easily tunable pores, and plasmonic properties, has attracted much interested in the field of nanotechnology. It has promising applications in the fields of catalysis, bio/chemical sensing, drug delivery, biomolecules separation and purific...

Electrochemical processes have been extensively investigated for the removal of a range of organic and inorganic contaminants. The great majority of these studies were conducted using nitrate-, perchlorate-, sulfate-, and chloride-based electrolyte solutions. In actual treatment applications, organic and inorganic constituents may have substantial effects on the performance of electrochemical t...

HILE THE L o c a l H i s t o r y Col lec t ion and the U n i v e r s i t y A r c h i v e s a r e housed in the s a m e r o o m s and a d m i n i s t e r e d by the s a m e staff in the U n i v e r s i t y of R o c h e s t e r L i b r a r y , each h a s i ts o w n ident i ty , its dist inc t h i s to ry and its s e p a r a t e p u r p o s e s and goals . T h e re l a t ionsh ip of the t w o col ...

The potentiodynamic behaviour of copper in brine solutions was studies. Auger and photo-electron spectroscopy were used together with electrochemical methods. It is demostrated that the passivation observed in potentiodynamic curves is due to a surface film formation on a copper electrode. It is concluded that this film must be copper (I) chloride in nature. Effect of different factors on poten...

The fact that oxidation, as one of the main routes of phase I metabolism of drugs, follows by conjugation reactions, and also formation of nitrenium ion as one of the clozapine oxidation products, directed us to investigate the oxidation of clozapine (CLZ) in the presence of nucleophile. The oxidation of clozapine (CLZ) has been studied on a glassy carbon electrode in the absence and presence o...