INTRODUCTION Mechanical ventilation (MV) is a life saving intervention in acute respiratory failure without alternative. However, particularly in pre-injured lungs, even protective ventilation strategies may evoke ventilator-induced lung injury (VILI), which is characterized by pulmonary inflammation and vascular leakage. Adjuvant pharmacologic strategies in addition to lung protective ventilat...

BACKGROUND Sanfilippo syndrome type B (MPS III B) is caused by a deficiency of α-N-acetylglucosaminidase enzyme, leading to accumulation of heparan sulfate within lysosomes and eventual progressive cerebral and systemic multiple organ abnormalities. However, little is known about the competence of the blood-brain barrier (BBB) in MPS III B. BBB dysfunction in this devastating disorder could con...

Chilling injury is sustained by dry pollen of Typha latifolia L. upon hydration in germination medium at 0 degrees C. This injury is evidenced as poor germination, low vigor, and depressed respiration. Isolated mitochondria showed multiple sites of impaired electron transport. Besides losses of cytochrome (Cyt) c and NAD(+), the activities of membrane-bound enzyme complexes such as Cyt oxidase,...

Silicon detectors produced from materials with different doping and oxygen concentration have been irradiated with 27 MeV and 23 GeV protons, 192 MeV pions and 5.3 MeV neutrons. In isothermal annealing studies at 60°C the microscopic defect evolution (measured with DLTS) and the changes in the detector leakage current were monitored in parallel. It is shown that the annealing of a broad DLTS pe...

Leakage resilient cryptography designs systems to withstand partial adversary knowledge of secret state. Ideally, leakage-resilient systems withstand current and future attacks; restoring confidence in the security of implemented cryptographic systems. Understanding the relation between classes of leakage functions is an important aspect. In this work, we consider the memory leakage model, wher...

Photodynamic therapy with bacteriochlorin a (BCA) as sensitizer induces damage to red blood cells in vivo. To assess the extent of the contributuion of reactive oxygen species (ROS) and to determine a possible reaction mechanism, competition experiments with assorted ROS quenching or/and enhancing agents were performed in human erythrocytes as model system and in phosphate buffer. In the erythr...

This paper investigated the back-barrier (BB) effect for gallium nitride (GaN)-based high-electron-mobility transistors with an Fe-doped buffer and Fe-buffer + Indium (InGaN)-BB structure. The authors found that InGaN-BB structure was effective in reducing off-state leakage current compared to buffer. Secondary-ion-mass spectrometry measurements revealed segregated Fe existed peaks at ∼2 × 1017...

A single-electron quantum dot device is an ideal environment to demonstrate the concept of a spin-based quantum bit, a promising candidate to realize a quantum computer. Two-dimensional electron gases (2DEGs) in silicon/silicon germanium heterostructures have been considered as a potential platform to fabricate singleelectron quantum dots for spin manipulations because silicon has an inherently...