The objective of this study was to assess the phenotypic susceptibility of HIV-1 subtype C isolates, with nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance-associated amino acid changes, to newer NNRTIs. A panel of 52 site-directed mutants and 38 clinically derived HIV-1 subtype C clones was created, and the isolates were assessed for phenotypic susceptibility to etravirine (ETR)...

BACKGROUND Two nucleoside reverse transcriptase inhibitors (NRTIs) and efavirenz (EFV) is a recommended initial regimen for HIV-1. Most EFV-related central nervous system (CNS) toxicity resolves early though symptoms may persist; we studied switching to etravirine (ETR) in these individuals. METHODS A randomized, double-blind trial in patients with viral suppression but ongoing CNS adverse ev...

Title of Dissertation: Investigation into the Driving Force Dependence of Excess Electron Transport in DNA Neil Peter Campbell Doctor of Philosophy, 2009 Dissertation Directed by: Professor Steven E. Rokita Department of Chemistry and Biochemistry The purpose of this dissertation is to investigate the driving force dependence of excess electron transport in deoxyribonucleic acid (DNA) using nap...

The analysis of the irradiance responses of photosynthetic processes, such as the quantum efficiencies of electron transport by photosystems I and II (PSI and PSII) or the rate of carbon dioxide fixation, is limited by the lack of mechanistically based analytical model for these processes. Starting with a model of P700 redox state, we develop a series of analytical functions which can be used t...

Trigonostemon reidi`oides (TR) is used as a Thai traditional medicine for the treatment of drug addiction, asthma, food poisoning, constipation and snake bites. The present study investigated the effects and molecular mechanisms of the ethanolic extract of TR (ETR) on mitogen-induced human umbilical vein endothelial cells (HUVECs) responses, proliferation, adhesion, migration and tube formation...

BACKGROUND IEtravirine (ETR) was approved in France in Sept 2008, to be used in combination with a ritonavir-boosted protease inhibitor (bPI) and others antiretrovirals (ARV) in HIV-infected pre-treated patients. OBJECTIVES To describe in a real life setting efficacy and tolerability of ETR-including regimen and factors associated with virologic response. METHOD In the French DatAIDS cohort...

Several factors which regulate the synthesis of enterotoxin B were examined in Staphylococcus aureus S-6 and in its heme-requiring mutant S-6H2. The kinetics of enterotoxin B synthesis during anaerobic growth were identical to those observed under aerobic conditions; extracellular enterotoxin accumulated in the medium during the transition between exponential and stationary phase growth. Strain...

<em><span lang="EN-US">The study aims to prove the relationship between earnings management (return on asset, asset intensity, inventory intensity) and corporate governance (independent commissioners, audit committee) tax avoidance, which is based two measurements (effective rate accounting profit minus taxable that divided by total asset). The sample in this are 114 companies engag...

Embryonic lethal abnormal vision (ELAV) type RNA binding protein 3 (ETR-3; also called NAPOR, CUGBP2, or BRUNOL3) has been implicated in the regulation of nuclear and cytoplasmic RNA processing events, including alternative splicing, RNA editing, stability and translation. Here, we report that the ETR-3 protein contains multiple regions that control its subcellular localization and are importan...