The paper considers a synergistic analysis of the physical and physiological nature electrical processes in human heart, namely most important biosystem – conduction nervous system heart (CNSH), particular, pacemaker. Currently, promising methods for studying CNSH as an active medium are being actively developed, using foundations nonlinear dynamics. Methods describing media widely used study p...

Permanent pacemaker implantation improves survival but can cause tricuspid valve dysfunction in the form of regurgitation (TR). The dominant mechanism pacemaker-mediated TR is lead impingement. This study evaluated association between location leads crossing and incidence worsening impingement using fluoroscopy. Lead positions were perpendicular right anterior oblique (RAO) parallel left (LAO) ...

INTRODUCTION Evidence suggests that the rate of cardiovascular implantable electronic device (CIED) infections is increasing more rapidly than the rates of CIED implantation and is associated with considerable mortality, morbidity and health economic impact. Antimicrobial surface treatments are being developed for CIEDs to reduce the risk of postimplantation infection within the subcutaneous im...

BACKGROUND Permanent pacemaker (PPM) implantation after cardiac surgery is required in 0.4-6% of patients depending on cardiac surgery type. PPM implantation in the early postoperative period may reduce morbidity and postoperative hospital stay. We performed a retrospective review of electronic medical records of adult patients with coronary artery bypass grafting (CABG), valve surgery, or both...

BACKGROUND With the increasing use of cardiac implantable electronic devices (CIED), there has been an associated increase in rate of complications. Infection accounts for about 1% of these, of which only a handful were reported secondary to Aspergillus fumigatus. All of these were seen in chronically-ill patients with several co-morbid conditions within a few years of implantation. None have b...

INTRODUCTION A permanent pacemaker is frequently needed after transcatheter aortic valve implantation, but the available data are mainly on the CoreValve system. OBJECTIVE To evaluate the need for new permanent pacemaker after implantation of the Edwards Sapien device, as well as related factors. METHODS We included the first 100 patients treated with the Edwards Sapien device at our instit...

Pacemaker cells are involved in regulating numerous essential biological functions. These cells exhibit spontaneous activities in isolation, due to the various membrane ion channels. Background conductances (ILeak) are responsible for the depolarized resting membrane potential of numerous pacemaker cells, largely due to a high sodium component (INa Leak); however, their molecular identity remai...

BACKGROUND To analyze the 10-year experience of single chamber permanent epicardial pacemaker placement for children with congenital heart diseases (CHD) after surgical repair. METHODS Between 2002 and 2014, a total of 35 patients with CHD (age: 26.9 ± 23.2 months, weight: 9.7 ± 5.6 kg) received permanent epicardial pacemaker placement following corrective surgery. Echocardiography and progra...

AIMS After decades of experience and strongly improved technology, service time of pacemaker generators is expected to increase. To test this hypothesis, we conducted a retrospective review of a large cohort of patients with a pacemaker. METHODS We reviewed data collected between 1984 and 2006 in the first national Dutch pacemaker registry. This registry covered 96% of all generators implante...

Circadian pacemaker neurons in the Drosophila brain control daily rhythms in locomotor activity. These pacemaker neurons can be subdivided into early or late groups depending on whether rhythms in period (per) and timeless (tim) expression are initiated at the first instar (L1) larval stage or during metamorphosis, respectively. Because CLOCK-CYCLE (CLK-CYC) heterodimers initiate circadian osci...