OBJECTIVE It is well known that intracerebroventricular (ICV) and supraspinal injections of orexin-A elicit analgesia, but the mechanism(s) of action remains unidentified. This study aims to characterize the effect of orexin-A on rostral ventromedial medulla (RVM) neurons which are involved in the descending nociception modulating pathway. MATERIALS AND METHODS In this experimental study, we ...

AIMS (1) To correlate atrial tachyarrhythmia (AT) burden of pacemaker-recipient Brady-Tachy syndrome (BTS) patients with a number of diagnostics-derived parameters after 1 month of DDD pacing; (2) to asses whether the activation of atrial overdrive or conventional rate-responsive pacing may affect relevant variables and their correlation. METHODS AND RESULTS After 1 month of DDD pacing, rate-...

OBJECTIVE The study aims to demonstrate the impact of some preoperative clinical parameters on the functional outcome of patients sustaining brachial plexus injuries, and to trace some commentaries about the use of intraoperative monitoring techniques. METHOD A retrospective study one hundred cases of brachial plexus surgery. The analysis regarding postoperative outcomes was performed by comp...

OBJECTIVE To evaluate the clinical and electrophysiological determinants of arrhythmia recurrence in patients undergoing internal atrial cardioversion for chronic atrial fibrillation (AF). SETTING Tertiary cardiac referral centre. METHODS 101 consecutive patients with failed external cardioversion or AF > or = 1 year underwent internal atrial cardioversion; once stable sinus rhythm (SR) was...

BACKGROUND The conventional right ventricle (RV) endocardial pacing leads QRS widening and desynchronization myocardial compromising ventricular function. With the need for stimulation less deleterious, RV septal pacing has been used more. Eventually have been reported higher thresholds and smaller R waves in the septal stimulation. OBJECTIVE To compare the parameters of the septal and apical...

objective: transplantation of bone marrow stromal cells (bmscs) or schwann cells (scs) can facilitate axonal regeneration in peripheral nerve injuries. the aim of this study was to compare the effects of transplantation of bmscs and scs on functional recovery after injury to the sciatic nerve in the rat. materials and methods:in this experimental research, adult male wistar rats (n=24, 250-300 ...

Introduction. This article provides an overview of the problem sinus node dysfunction after surgical treatment for longstanding persistent atrial fibrillation and methods diagnosing initial states cardiac activity conduction. Purpose. To identify predictors in patients with long-standing fibrillation. Material Methods: The study comprised a total 65 complicating mitral valve disease. state auto...

Neural oscillations have emerged as one of the major electrophysiological phenomena investigated in cognitive and systems neuroscience. These oscillations are typically studied with regard to their amplitude, phase, and/or phase coupling. Here we demonstrate the existence of another property that is intrinsic to neural oscillations but has hitherto remained largely unexplored in cognitive and s...

Arrhythmias are usually present in up to 80% of the patients7, with prevalence of anomalous atrioventricular pathways ranging from 0 to 44%1-3. Despite the universal acceptance of electrophysiological study (EPS) in symptomatic patients or in those with apparent accessory pathway on the electrocardiogram (ECG), data on asymptomatic patients with no electrocardiographic evidence of pre-excitatio...

Introduction Focal atrial tachycardia (AT) accounts for 5%–15% of arrhythmias in adults who undergo electrophysiological study (EPS) for paroxysmal supraventricular tachycardia, and it can be generated by enhanced automaticity, triggered activity, and microreentry. Radiofrequency catheter ablation (RFCA) has been reported as a curative therapy for AT with a high success rate. While almost all i...