Purpose To investigate the genetic basis for severe visual complaints by Bukharan Jewish patients with oculopharyngeal muscular dystrophy (OPMD). Methods Polymerase chain reaction amplification and direct sequencing were used to test for NRL, PABPN1, and NR2E3 mutations. Complete ophthalmic examination included best-corrected visual acuity, biomicroscopic examination, optical coherence tomogr...

Electroretinography, a technique that objectively assesses the function of the retina, is used to evaluate the progression of retinal disorders. Part I of this two-part presentation discussed the morphologic and physiologic characteristics of the retina. The information presented in Part II can help practitioners determine when an electroretinogram (ERG) is recommended. In addition to the stand...

OBJECTIVES To evaluate the precision of retinal tissue dissection by the pulsed electron avalanche knife (PEAK) and to assess possible toxic effects from this device. METHODS To demonstrate precision of cutting, bovine retina (in vitro) and rabbit retina (in vivo) were incised with the PEAK. Samples were examined by scanning electron microscopy and histologic examination (light microscopy). T...

PURPOSE To report a previously unreported presentation of advanced geographic atrophy of the macula mimicking nonneovascular (dry) age-related macular degeneration in a patient with light chain deposition disease. METHODS Ocular examination included dilated fundus examination, fundus autofluorescence, full-field electroretinography, and spectral domain optical coherence tomography. PATIENTS...

The authors evalute the visual functions of patients with unilateral central serous chorioretinopathy (CSC) and compare them with their non-affected eye and with a control group. Fourteen patients with CSC treated with direct laser-photocoagulation were examined preoperatively and followed-up, up to 2 years postoperatively. Baseline best corrected visual acuity (BCVA) and contrast sensitivity (...

The pattern electroretinogram (PERG) findings in 72 patients with disease of the anterior visual pathways are presented in relation to the site of dysfunction. Two components of the PERG are described which are selectively involved in different pathologies. In particular, the main positive P50 component is invariably affected in retinal/macular dysfunction, whereas the late negative N95 compone...

PURPOSE To assess the applicability of multifocal electroretinograms (mfERGs) for evaluation of function in this small-eyed animal with a rod-dominant retina that is often used to model retinal diseases. METHODS Noninvasive monocular mfERGs were recorded in anesthetized albino (Sprague-Dawley) and pigmented (Long Evans) rats. Achromatic stimuli subtending a 49 degrees by 53 degrees field cons...

Full-field electroretinography is an objective measure of retinal function, serving as an important diagnostic clinical tool in ophthalmology for evaluating the integrity of the retina. Given the similarity between the anatomy and physiology of the human and Green Monkey eyes, this species has increasingly become a favorable non-human primate model for assessing ocular defects in humans. To tes...

Introduction: Multifocal electroretinography (ERG) is an examination which measures retinal electrical activity as a response to lighting stimulus and allows simultaneous recording in many topographic locations. Various electrodes have been developed balance accuracy also patients’ comfort. The objective of this study establish normal values multifocal ERG compare the comfort level using Jet, D...

THE existence of an electrical potential in the vertebrate eye, with the cornea positive to the fundus, was demonstrated over a century ago (Du Bois-Reymond, 1849). This potential, the standing or corneo-fundal potential, is often described as a steady potential to distinguish it from the rapidly oscillating potential of the electroretinogram. It is not, however, a truly steady potential, but i...