Introduction: Previous studies have shown that cannabinoidergic system is involved in anxiety. However, there are controversial reports in the experimental studies. The aim of this study is to evaluate the effect of pharmacological stimulation or blocking of CB1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze (EPM) test in rat. The EPM is o...

Due to its complexity, in combination with a lack of scientific reports, fur-chewing became one of the most challenging behavioral problems common to captive chinchillas. In the last years, the hypothesis that fur-chewing is an abnormal repetitive behavior and that stress plays a role in its development and performance has arisen. Here, we investigated whether a relationship existed between the...

Beta-carotene (BC) is a precursor of vitamin A and an excellent antioxidant. It protects the vascular system. Vascular dementia (VaD) one aging disorders causing memory dysfunction. The available medicines for management VaD are limited. present study aimed to evaluate ameliorative effect BC in streptozotocin (STZ)-induced diabetic rats. Diabetic was induced through administration nicotinamide ...

α-Galycoceramide (α-Galcer) or the common name of krn7000 is an α-gelasphin derivative. The α-Galcer structure consists of a galactose combined with a ceramide in an α-configuration. Social isolation (SI) has been linked with enhanced inflammation, through modifications in transcriptional pathways linked with glucocorticoid, to stress. Our hypothesis is to investigate mediatory role of glucocor...

The roots of Withania somnifera (L) Dunal (W. somnifera) are used extensively in Ayurveda, the classical Indian system medicine, and W. is categorized as a rasayana, which to promote physical mental health, provide defense against disease adverse environmental factors arrest aging process. has been stabilize mood patients with behavioural disturbances. objective this study was investigate pharm...

BC1 RNA is a small non-messenger RNA common in dendritic microdomains of neurons in rodents. In order to investigate its possible role in learning and behaviour, we compared controls and knockout mice from three independent founder lines established from separate embryonic stem cells. Mutant mice were healthy with normal brain morphology and appeared to have no neurological deficits. A series o...

Research on new compounds of therapeutic value for behavioral disorders has progressed recently. Several studies have reported neuropharmacological activities of plant derived terpenes. Farnesol is a sesquiterpene whose most popular source is fruits but the anxiolytic activity for farnesol is still unknown. The present study was conducted on 32 male Swiss Albino mice (8 in each group) to evalua...