introduction: many epidemiological studies have been conducted to determine the prevalence of the various types of the dental anomalies. the aim of the present study was determination of developmental and acquired dental anomalies in patients attending the faculty of dentistry in rasht, iran. materials and methods: in this retrospective cross-sectional study, 1224 digital panoramic ra-diographs...

Despite the father transmitting half the heritable information to the embryo the focus on preconception health has largely been on the mother. New studies highlight the role of the father in disease transmission via non-genetic inheritance, through epigenetic mechanisms. Epigenetic mechanisms include, DNA methylation, post-translational modifications of histones and noncoding RNAs. Paternal eff...

1 Although genetic and inherited disorders are individually rare, they collectively affect about one in 17 individuals in Western population 1. Genetic abnormalities at conception are more common and many of them become incompatible for embryo survival. In fact, chromosome abnormalities in embryo account for about 50% first trimester pregnancy losses. Most of these genetic abnormalities are num...

Abstract Study question Are there differences in recombination rates between male and female embryos, is the frequency of associated with risk aneuploidy? Summary answer There more meiosis than males. Aneuploidy fewer events. Genome-wide reduction predisposes oocytes to aneuploidy. What known already believed be primary explanation for embryo implantation failure miscarriage is, therefore, grea...

Abstract Study question Can deep learning models using time-lapse images of embryo development be used to predict ploidy and provide supplemental information embryologists for clinical decision-making? Summary answer We developed a general MDBS-Ploidy model that uses maternal age quality scores status. What is known already Ploidy status, or the presence lack chromosomal abnormalities, an impor...

BACKGROUND A correlation between morphology, developmental competence and chromosome abnormalities is established. However, since absolute correlations are rare, embryo selection remains one of the most arduous tasks in assisted reproduction. This study was undertaken in order to determine which chromosomal abnormalities are compatible with development to the blastocyst stage. METHODS Embryos...

Folic acid supplementation can prevent many cases of neural tube defects (NTDs), whereas suboptimal maternal folate status is a risk factor, suggesting that folate metabolism is a key determinant of susceptibility to NTDs. Despite extensive genetic analysis of folate cycle enzymes, and quantification of metabolites in maternal blood, neither the protective mechanism nor the relationship between...

OBJECTIVE To evaluate the patterns of chromosome abnormalities in embryos derived from intracytoplasmic sperm injection (ICSI) in microsurgical epididymal sperm aspiration (MESA) or testicular sperm extraction (TESE) in comparison to embryos that are derived from naturally ejaculated (EJAC) patients. MATERIALS AND METHODS Male partners with azoospermia who required MESA or TESE for ICSI were ...

Pesticides may be involved in oyster summer mortality events, not necessarily as a single causative agent but as an additional stressor. In this context, the present study aimed to assess the toxicity of glyphosate, its by-product, aminomethylphosphonic acid (AMPA) and two commercial formulations, Roundup Express(®) (R(EX)) and Roundup Allées et Terrasses(®) (R(AT)), containing glyphosate as th...

The neural crest (NC) represents multipotent cells that arise at the interphase between ectoderm and prospective epidermis of the neurulating embryo. The NC has major clinical relevance because it is involved in both inherited and acquired developmental abnormalities. The aim of this study was to establish an experimental platform that would allow for the integration of human NC cells (hNCCs) i...