[This corrects the article on p. 424 in vol. 6, PMID: 26113852.].

In this issue of Molecular Pharmacology, Meyn et al. (p. 1320) provide the results of the first comprehensive investigation of the expression pattern of the Src family of nonreceptor tyrosine kinases (SFK) in mouse embryonic stem (ES) cells. They found that self-renewing ES cells express seven of the eight mammalian SFK members and that some undergo distinct expression changes during early diff...

Symmetry-breaking transitions associated with the buckling and folding of curved multilayered surfaces-which are common to a wide range of systems and processes such as embryogenesis, tissue differentiation and structure formation in heterogeneous thin films or on planetary surfaces-have been characterized experimentally. Yet owing to the nonlinearity of the underlying stretching and bending fo...

Convergent morphologies often arise due to similar selective pressures in independent lineages. It is poorly understood whether the same or different developmental genetic mechanisms underlie such convergence. Here we show that independent evolution of a reproductive trait, ovariole number, has resulted from changes in distinct developmental mechanisms, each of which may have a different underl...

objective: vitrification has been shown as one of the most effective methods of cryopreservation for mammalian embryos. however, there is no consensus which stage of embryonic development is the most appropriate for vitrification with subsequent maximal development after thawing. this study was carried out to explore and compare the effect(s) of vitrification on mouse 2-cell, 4-cell, 8-cell, mo...

Methylmercury (MeHg) is an organic form of mercury that can damage the developing brains of human fetuses. Women who consume methylmercury during pregnancy [2] can bear children who have neurological issues because methylmercury has toxic effects on the nervous system during embryonic development. During the third week of gestation [3], the human nervous system begins to form in the embryo. Dur...

Methylmercury (MeHg) is an organic form of mercury that can damage the developing brains of human fetuses. Women who consume methylmercury during pregnancy [2] can bear children who have neurological issues because methylmercury has toxic effects on the nervous system during embryonic development. During the third week of gestation [3], the human nervous system begins to form in the embryo. Dur...

The mature heart may be thought of as consisting of three layers, endocardium, myocardium, and an outer investing tissue called the epicardium. During early formation of the tubular heart of chick embryos, at about the 8-somite stage, two tissue layers become clearly discernible with the light microscope: the endocardium and the developing myocardial wall. The outer epicardial layer does not ap...

Methylmercury (MeHg) is an organic form of mercury that can damage the developing brains of human fetuses. Women who consume methylmercury during pregnancy [2] can bear children who have neurological issues because methylmercury has toxic effects on the nervous system during embryonic development. During the third week of gestation [3], the human nervous system begins to form in the embryo. Dur...

Testicular development is a very interesting aspect of male reproduction and fertility. The primordial germ cells migrate from yolk sac to the genital ridge along the wall of the hindgut and the dorsal mesentery to ultimately settle in the genital ridge that would give rise to testes. Sex-determining region of the Y chromosome (SRY) is the principal driver of testes development. Testes developm...