Peterka M., M. Tu~ek, D. Vesely: EmbryotoxicityoJNineSeedMordants in the Chick Embryo the CHEST Method. Acta vet. Bmo 1996, 65:213-217. The seed mordants Agronal Super, which contains the organic mercury (5.4% phenylmercurychloride), has appeared to induce poisoning and even death of many people and animals. Minimal single embryotoxic doses of Agronal Super were estimated in 2-4-day old chick e...

Aqueous extract of Indigofera suffruticosa leaves obtained by infusion was used to evaluate the oviposition, its effect on development of eggs and larvae, and morphological changes in larvae of Aedes aegypti. The bioassays were carried out with aqueous extract in different concentrations on eggs, larvae, and female mosquitoes, and the morphological changes were observed in midgut of larvae. The...

Laboratory studies have suggested that some alkylphenols and pesticides elicit developmental toxicity to crustaceans. The purpose of the present study was to evaluate the possibility that the alkylphenol degradation product 4-nonylphenol is embryotoxic to the crustacean Daphnia magna through its known ability to interfere with the metabolic elimination of testosterone. Direct exposure of matern...

Cognitive dysfunctions are the main symptoms associated with Alzheimer's disease (AD). In last decade, use of natural substances to prevent or alleviate neurological have attracted great interest. Curcumin, polyphenolic component turmeric ( Curcuma longa ) rhizomes, has a variety beneficial properties, including potent antioxidant and anti-inflammatory properties. Despite therapeutic potential ...

Zebrafish embryos were exposed to concentration ranges of selected thyroid-active model compounds in order to assess the applicability of zebrafish-based developmental scoring systems withinan alternative testing strategy to detect the developmental toxicity ofthyroid-active compounds. Model compounds tested included triiodothyronine (T3), propylthiouracil (PTU), methimazole (MMI), sodium perch...

The zebrafish embryotoxicity test (ZET) is considered a promising alternative model in predictive toxicology. Currently, morphological assessment of the embryo is the main readout for this assay. However, implementation of transcriptomics may help to detect more subtle effects, which may increase the sensitivity and predictability of the test. In this study, we tested a concentration response o...

BACKGROUND Methotrexate (MTX), as an anti-folate agent, is widely used in the treatment of rheumatic disorders and malignant tumors, however it damages reproductive sys- tem in mice. The aim of this research was to study the effects of ethyl pyruvate (EP) on embryo development and oxidative stress changes in the testis of mice treated with MTX. MATERIALS AND METHODS In this experimental study...

Many pesticides have been documented to induce embryotoxicity and teratogenicity in non-target aquatic biota such a fish, amphibians and invertebrates. Our review of the existing literature shows that a broad range of pesticides, representing several different chemical classes, induce variable toxic effects in aquatic species. The effects observed include diverse morphological malformations as ...