Childhood cancer survivors (CCS) experience higher hospitalization rates compared to the general population for neoplasms, circulatory diseases, endocrine/nutritional/metabolic diseases and eye disorders. We studied trends in hospitalization rates and associated patient and treatment-specific risk factors for diagnosis subgroups among these four diseases. We performed medical record linkage of ...

With this issue, we launch Clinical Diabetes and Endocrinology (CDE), a new journal for health researchers and professionals involved in the care of people with diabetes and endocrine diseases. CDE is published collaboratively by the University of Michigan and our partners at BioMed Central. Our vision is to share new research and clinical knowledge in diabetes and endocrine diseases with the h...

A mathematical model is proposed to allow expressive representation of endocrine systems by graphic means. The differential equations exactly describing the system can be formulated easily and automatically by the graphic model. Different kinds of software are supposed to solve these equations easily. Chaotic operational range can be found by fitting the parameters of equations. The results can...

The endothelium plays a vital role in maintaining circulatory homeostasis by the release of relaxing and contracting factors. Any change in this balance may result in a process known as endothelial dysfunction that leads to impaired control of vascular tone and contributes to the pathogenesis of some cardiovascular and endocrine/metabolic diseases. Reduced endothelium-derived nitric oxide (NO) ...

INTRODUCTION Autoimmune diseases are chronic conditions initiated by the loss of immunological tolerance to self-antigens. They constitute heterogeneous group of disorders, in which multiple alterations in the immune system result in a spectrum of syndromes that either target specific organs or affect the body systematically. Recent epidemiological studies have shown a possible shift of one aut...

Abstract Coeliac disease (CD, sometimes called gluten-sensitive enteropathy or nontropical sprue) is an inflammatory disorder of the small intestine of autoimmune origin. It occurs in genetically predisposed people and is induced by a gluten protein, which is a component of wheat. The prevalence of histologically confirmed CD is estimated in screening studies of adults in the United States a...

BACKGROUND Cancer is associated with an increased risk of thromboembolic diseases, but data on the association between prostate cancer and thromboembolic diseases are scarce. We investigated the risk of thromboembolic disease in men with prostate cancer who were receiving endocrine treatment, curative treatment, or surveillance. METHODS We analysed data from PCBaSe Sweden, a database based on...

Today, adipokines are important cellular signaling proteins synthesized by adipose tissue and involved in a variety of processes, including inflammation, lipid glucose metabolism, insulin sensitivity, endothelial cell function, angiogenesis, blood pressure regulation, many others. This review examines the immunological endocrine function omentin its potential use as biomarker therapeutic target...

Based on epidemiological observations Barker et al. put forward the hypothesis/concept that an adverse intrauterine environment (involving insufficient nutrient supply, chronic hypoxia, stress, and toxic substances) is important risk factor for development of diseases later in life. The fetus responds to unfavorable with adaptive reactions, which ensure survival short run, but at expense initia...