abstractbackground: delivering the radiation dose to the target volume and minimizing the dose to normal tissues are the main objectives in radiotherapy. the aim of our study is to enhance the contrast of the portal image to increase the accuracy of delineation of the organs in the irradiation field.   methods: the software was written based on local enhancement of the pixel values in image mat...

BACKGROUND Isolated hypothalamic-pituitary Langerhans cell histiocytosis (HPLCH) is very rare. We investigated the clinicopathological characteristics, endocrine function changes, BRAFV600E mutations and treatments of isolated HPLCH. METHODS We identified seven patients with isolated HPLCH by reviewing the clinical and pathological files in our hospital from 2007 to 2015. The clinical charact...

A 75-year-old woman was admitted to our hospital because of a poor glycemic control. She was found to have Cushingoid feature and dynamic endocrine tests showed elevated plasma ACTH and cortisol levels, lack of their circadian rhythm, non-suppressibility to high-dose dexamethasone, responsiveness to CRH, but not to DDAVP, and suppression to octreotide. Pituitary MRI showed an equivocal small le...

BACKGROUND Insulinoma is a pancreatic neuroendocrine tumor originated from pancreatic islet beta cells. Although rare, is the most common pancreatic endocrine tumor, with about four cases per million people. The preferential treatment of insulinoma is surgical. AIM To analyze the epidemiological, pathological, clinical and surgical patients treated in the last decade in two surgical services....

During development, the pancreatic endocrine cells are specified within the epithelium. They will subsequently delaminate and migrate out of the epithelium in order to form the islets. Neurogenin3 (Ngn3) is a bHLH transcription factor that is responsible for differentiation of all endocrine cell types, but whether or not it has a role in their migration is still an open question. By using the c...

During development, the pancreatic endocrine cells are specified within the epithelium. They will subsequently delaminate and migrate out of the epithelium in order to form the islets. Neurogenin3 (Ngn3) is a bHLH transcription factor that is responsible for differentiation of all endocrine cell types, but whether or not it has a role in their migration is still an open question. By using the c...

During development, the pancreatic endocrine cells are specified within the epithelium. They will subsequently delaminate and migrate out of the epithelium in order to form the islets. Neurogenin3 (Ngn3) is a bHLH transcription factor that is responsible for differentiation of all endocrine cell types, but whether or not it has a role in their migration is still an open question. By using the c...

Zollinger-Ellison syndrome (ZES) is a rare disease. Its management concerns symptoms related to the gastric acid overproduction that characterizes the syndrome and to the gastrin-producing tumor(s) usually located in the duodenal wall and/or the endocrine pancreas. Acid hypersecretion is now controlled by the use of powerful antisecretory agents. Management of the malignant process(es) has beco...

During development, the pancreatic endocrine cells are specified within the epithelium. They will subsequently delaminate and migrate out of the epithelium in order to form the islets. Neurogenin3 (Ngn3) is a bHLH transcription factor that is responsible for differentiation of all endocrine cell types, but whether or not it has a role in their migration is still an open question. By using the c...

AIM To evaluate long term detailed pancreatic endocrine and exocrine function in children with persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI) after 85-95% pancreatectomy. METHODS Six children with PHHI between 0.9 and 12.7 years after pancreatic resection underwent clinical and investigative follow up at 1.0 to 14.9 years of age. One child with PHHI who had not had pancreatectom...