Background: Angiogenesis initiated by cancerous cells is the process by which new blood vessels are formed to enhance oxygenation and growth of tumor. Objective: In this paper, we present a new multiscale mathematical model for the formation of a vascular network in tumor angiogenesis process. Methods: Our model couples an improved sprout spacing model as a stochastic mathematical model of spro...

Blood vessels are composed of two types interacting cells. Endothelial cells form the inner lining vessel wall, and perivascular referred to as pericytes, vascular smooth muscle or mural which envelop surface tube. They also called Rouget after their discoverer, Charles Rouget. Electron-microscope analyses first revealed morphological character pericytes. In general, pericytes possess a cell bo...

Adhesion between cancer cells and endothelial cells, lining the blood vessels, is an important event in tumor progression metastasis formation. The expression of Rho GTPases frequently altered cancers, they are known to regulate cell migration through their effects on adhesion cytoskeletal dynamics. Several different types assays used investigate how attach cross endothelium. Here, we describe ...