Introduction: The recruitment of leukocytes into the vessel wall intima plays a significant role in the onset and progression of atherosclerotic lesions. Imaging of VCAM-1 expression in atherosclerotic plaques may serve as a surrogate marker of inflammatory cell recruitment into plaques. The purpose of this study was to image VCAM-1 expression in carotid artery lesions of apoE-/mice, to compare...

In a communication shortly to be published* we are recording a case of bilateral ovarian neoplasms in an infant with generalized reticuloendotheliosis and monocytic leuka!mia. The histology of the ovaries showed the tumours to be endotheliomata. The following were the chief features of this case. M. D., aged 1 year, was admitted for wasting, under Dr. Smellie, to the Birmingham Children's Hospi...

Previously we have shown that high metastatic colonic carcinoma cells express relatively more lamp molecules and sialyl Le(x) structures on the cell surface than their corresponding low metastatic counterparts (Saitoh, O., Wang, W.-L., Lotan, R., and Fukuda, M. (1992) J. Biol. Chem. 267, 5700-5711). In the present study, we extended these findings by testing whether these high and low metastati...

Many neurodegenerative disorders (NDDs) are characterized by aggregation of aberrant proteins and extensive oxidative stress in brain cells. As a treatment option for NDDs, RNA interference (RNAi) is a promising approach to suppress the activation of abnormal genes and negative regulators of antioxidant genes. Efficient neuro-targeted siRNA delivery requires a delicate optimization of nucleic a...

MCCAUGHEY, W.T.E. (1958) Primary tumours of the pleura. Journal of Pathology and Bacteriology, 86, 517. NEWHOUSE, M.L. & THOMPSON, H. (1965) Mesothelioma of the pleura and peritoneum following exposure to asbestos dust in the London area. British Journal of Industrial Medicine, 22, 261. NIXON, P.F., WOLFENDEN, W.H. & HIRST, E. (1964) Paraplegia and destruction of the ribs. Medical Journal of Au...