Optical Doppler tomography is a valuable functional extension of optical coherence tomography (OCT) that can be used to study subsurface blood flows of biological tissues. We propose a novel frequency estimation technique that uses an adaptive notch filter (ANF) to track the depth-resolved Doppler frequency. This new technique is a minimal-parameter filter and works in the time domain without t...

We established a strategy to perform cross-validation of serial optical coherence scanner imaging (SOCS) and diffusion tensor imaging (DTI) on a postmortem human medulla. Following DTI, the sample was serially scanned by SOCS, which integrates a vibratome slicer and a multi-contrast optical coherence tomography rig for large-scale three-dimensional imaging at microscopic resolution. The DTI dat...

Optical coherence tomography is a well-known technique for the optical imaging biological tissues. However, depth scanning range of high-resolution restricted by its focus. In this study, Zinc Selenide (ZnSe) Microlens Array (MLA) employed to overcome depth-of-focus limitation tomography. The ZnSe material with low Abbe number and high chromatic dispersion extends focus transverse resolution. M...

INTRODUCTION To describe the characteristics, diagnosis, and treatment of the first documented case of Vogt-Koyanagi-Harada (VKH) disease following BCG vaccination (Patient 1) and the first documented case of both VKH disease and tuberculosis (Patient 2). Two patients were diagnosed with VKH disease and monitored using fundus photography, fundus autofluorescence, fluorescein angiography (FA), s...

BACKGROUND The purpose of this study was to examine the choroidal thickness of patients with high myopia using enhanced depth imaging optical coherence tomography (EDI-OCT) and compare them with healthy subjects. METHODS We first conducted a cross-sectional study and then performed a meta-analysis to address this issue further. Using enhanced depth imaging optical coherence tomography (EDI-OC...

Purpose To compare cross-sectional choroidal morphology in rhesus macaque and human eyes using enhanced-depth imaging optical coherence tomography (EDI-OCT) and histologic analysis. Methods Enhanced-depth imaging-OCT images from 25 rhesus macaque and 30 human eyes were evaluated for choriocapillaris and choroidal-scleral junction (CSJ) visibility in the central macula based on OCT reflectivit...

A critical method of monitoring patients with neovascular age-related macular degeneration (AMD) being treated with anti–vascular endothelial growth factor (anti-VEGF) is optical coherence tomography (OCT), which uses low-coherence interferometry of light to examine the retina in vivo on a micrometer scale. Recent advances in spectral-domain OCT make visualization of the choroid feasible. Using...

PURPOSE To examine subfoveal choroidal thickness (SFCT) in eyes with glaucoma, using enhanced depth imaging spectral domain optical coherence tomography. METHODS The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years (range: 50-93 years). A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography (S...

PURPOSE To evaluate choroidal thickness in young adults using enhanced-depth imaging spectral-domain optical coherence tomography and to describe volume differences in all the areas defined in the Early Treatment Diabetic Retinopathy Study. DESIGN Prospective clinical study. METHODS In 95 healthy young (23.8 ± 3.2 years) adult volunteers, 95 eyes were prospectively enrolled. Manual choroida...

Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth-resolved cross-sectional images. In this study, OCT was used to detect changes in the optical properties of cortical tissue in vivo in mice during the induction of global (pentylenetetrazol) and focal (4-aminopyridine) seizures. Through the use of a confidence interval statisti...