In this article we review marital enrichment programs for the quality and research basis of material presented, adequacy of the leaders guide, processing of exercises, user friendliness for teaching and application, view of gender roles, and degree to which the program is integrated into a biblical/theological perspective. After considering the relative strengths and limitations of available pr...

Unlike text on paper, hypertext enables the linking of pieces of text with other texts and multimedia resources, which not only improves the way we read but also lays the foundation for new information systems. Specifically, the proliferation of collaborative sites, blogs, online databases, encyclopedias and many other services on the World Wide Web provides an invaluable source of up-to-date i...

MOTIVATION RIP-chip is a high-throughput method to identify mRNAs that are targeted by RNA-binding proteins. The protein of interest is immunoprecipitated, and the identity and relative amount of mRNA associated with it is measured on microarrays. Even if a variety of methods is available to analyse microarray data, e.g. to detect differentially regulated genes, the additional experimental step...

Motivation Deciphering relevant biological insights from epigenomic data can be a challenging task. One commonly used approach is to perform enrichment analysis. However, finding, downloading and using the publicly available functional annotations requires time, programming skills and IT infrastructure. Here we describe the online tool EpiAnnotator for performing enrichment analyses on epigenom...

We define the phrase ‘category enriched in an fc-multicategory’ and explore some examples. An fc-multicategory is a very general kind of 2-dimensional structure, special cases of which are double categories, bicategories, monoidal categories and ordinary multicategories. Enrichment in an fc-multicategory extends the (more or less well-known) theories of enrichment in a monoidal category, in a b...

Automatically creating semantic enrichments for text may lead to annotations that allow for excellent recall but poor precision. Manual enrichment is potentially more targeted, leading to greater precision. We aim to support non-experts in manually enriching texts with semantic annotations. Neither the visualisation of semantic enrichment nor the process of manually enriching texts has been eva...

Based on a Bayesian decision theoretic approach, we optimize frequentist single- and adaptive two-stage trial designs for the development of targeted therapies, where in addition to an overall population, a pre-defined subgroup is investigated. In such settings, the losses and gains of decisions can be quantified by utility functions that account for the preferences of different stakeholders. I...

The Motif Enrichment Tool (MET) provides an online interface that enables users to find major transcriptional regulators of their gene sets of interest. MET searches the appropriate regulatory region around each gene and identifies which transcription factor DNA-binding specificities (motifs) are statistically overrepresented. Motif enrichment analysis is currently available for many metazoan s...

MOTIVATION Multivariate experiments applied to mammalian cells often produce lists of proteins/genes altered under treatment versus control conditions. Such lists can be projected onto prior knowledge of kinase-substrate interactions to infer the list of kinases associated with a specific protein list. By computing how the proportion of kinases, associated with a specific list of proteins/genes...