BACKGROUND/AIMS Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (R-CHOP) has improved survival in patients with diffuse large B-cell lymphoma (DLBCL) and weakened the prognostic power of the international prognostic index (IPI). We evaluated the efficacy of the IPI and revised IPI (R-IPI) in patients with DLBCL who were treated with R-CHOP, focusing on ext...

BACKGROUND Neural stem and progenitor cells of the Enteric Nervous System (ENS) are regarded as a novel cell source for applications in regenerative medicine. However, improvements to the current ENS cell culture protocols will be necessary to generate clinically useful cell numbers under defined culture conditions. Beneficial effects of physiologically low oxygen concentrations and/or the addi...

The emerging edge computing (EC) paradigm promises to provide low latency and ubiquitous computation numerous mobile Internet of Things (IoT) devices at the network edge. How efficiently allocate geographically distributed heterogeneous resources a variety services is challenging task. While this problem has been studied extensively in recent years, most previous work largely ignored preference...

This paper describes the inside organization of Educative Networks (ENs) and the aspects that allowed their growth and success in the city of Barcelona, Spain. ENs emerged over the past ten years in Catalonia, Spain, as a way to incorporate social and educative challenges in the territory. These educative proposals are based on the connection between the different educative institutions in the ...

Glial-derived neurotrophic factor (Gdnf) is required for morphogenesis of the enteric nervous system (ENS) and it has been shown to regulate proliferation, differentiation, and survival of cultured enteric neural crest-derived cells (ENCCs). The goal of this study was to investigate its in vivo role in the colon, the site most commonly affected by intestinal neuropathies such as Hirschsprung's ...

This paper describes the inside organization of Educative Networks (ENs) and the aspects that allowed their growth and success in the city of Barcelona, Spain. ENs emerged over the past ten years in Catalonia, Spain, as a way to incorporate social and educative challenges in the territory. These educative proposals are based on the connection between the different educative institutions in the ...

Using an embryoid body (EB) culture system, we developed a functional organ-like cluster--a "gut"--from mouse embryonic stem (ES) cells (ES gut). Each ES gut exhibited spontaneous contractions but did not exhibit distinct peristalsis-like movements. In these spontaneously contracting ES guts, dense distributions of interstitial cells of Cajal (c-kit [a transmembrane receptor that has tyrosine k...

Aim. To investigate the abundance of neuroligin-1 and neurexin II in the enteric nervous system (ENS) of rats on different embryonic days and to explore their potential significance. Methods. The full-thickness colon specimens proximal to the ileocecal junction of rats on embryonic days 16, 18, and 20 and of newborns within 24 hours (E16, E18, E20, and Ep0) were studied, respectively. qRT-PCR w...